Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Adrenoleukodystrophy


Synonyms of Adrenoleukodystrophy
  • Addison Disease with Cerebral Sclerosis
  • Adrenomyeloneuropathy
  • ALD
  • AMN
  • Bronze Schilder Disease
  • Melanodermic Leukodystrophy
  • Schilder Disease
  • Siemerling-Creutzfeldt Disease
  • Sudanophilic Leukodystrophy
  • X- ALD

Disorder Subdivisions



    General Discussion
    Adrenoleukodystrophy is an X-linked recessive genetic disorder caused by an abnormality in the ABCD1 gene on the X chromosome. This condition affects the white matter of the nervous system and the adrenal cortex. Some affected individuals have adrenal insufficiency, which means that reduced amounts of certain hormones such as adrenaline and cortisol are produced, leading to abnormalities in blood pressure, heart rate, sexual development and reproduction. Some of those affected experience serious neurological problems that can affect mental function and lead to disability and reduced life span. This condition has been categorized into six types based on symptoms and age of onset: childhood cerebral ALD, adolescent cerebral ALD, adrenomyeloneuropathy, adult cerebral ALD, adrenal insufficiency only and ALD that occurs in females.

    Organizations related to Adrenoleukodystrophy
    • ALD Family Support Trust
      4 Morley House
      London Intl W1B 3BB
      Phone #: 020--76-31-3336
      800 #: --
      e-mail: info@aldfst.org.uk
      Home page: http://www.aldfst.org.uk
    • Australian Leukodystrophy Support Group, Inc.
      10 Mitchell Street
      Mentone, Victoria None 3194
      Phone #: 001-1(0-3)9584 7070
      800 #: N/A
      e-mail: leuko@vicnet.net.au
      Home page: http://www.alds.org.au
    • CLIMB (Children Living with Inherited Metabolic Diseases)
      Climb Building
      Crewe Intl CW2 6BG
      Phone #: +44- 87-0 7700 325
      800 #: --
      e-mail: info@climb.org.uk
      Home page: http://www.CLIMB.org.uk
    • ELA - European Association against Leukodystrophies
      2, rue Mi-les-Vignes
      Laxou None 54520
      Phone #: 33 -383- 30 93 34
      800 #: --
      e-mail: ela@ela-asso.com
      Home page: http://www.ela-asso.com
    • Fight ALD
      P.O. Box 3318
      Vista CA 92085
      Phone #: N/A
      800 #: N/A
      e-mail: info@fightald.org
      Home page: http://www.fightald.org
    • Hunter's Hope Foundation, Inc.
      PO Box 643
      Orchard Park NY 14127
      Phone #: 716-667-1200
      800 #: 877-984-4673
      e-mail: info@huntershope.org
      Home page: http://www.huntershope.org
    • Kennedy Krieger Institute
      707 North Broadway
      Baltimore MD 21205
      Phone #: 443-923-9200
      800 #: 800-873-3377
      e-mail: webmaster@kennedykrieger.org
      Home page: http://www.kennedykrieger.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • March of Dimes Birth Defects Foundation
      1275 Mamaroneck Avenue
      White Plains NY 10605
      Phone #: 914-428-7100
      800 #: 888-663-4637
      e-mail: Askus@marchofdimes.com
      Home page: http://www.marchofdimes.com
    • National Institute of Neurological Disorders and Stroke (NINDS)
      31 Center Drive
      Bethesda MD 20892-2540
      Phone #: 301-496-5751
      800 #: 800-352-9424
      e-mail: braininfo@ninds.nih.gov
      Home page: http://www.ninds.nih.gov/
    • The Arc (a national organization on mental retardation)
      1010 Wayne Ave
      Silver Spring MD 20910
      Phone #: 301-565-3842
      800 #: 800-433-5255
      e-mail: info@thearc.org
      Home page: http://www.thearc.org/
    • United Leukodystrophy Foundation
      2304 Highland Drive
      Sycamore IL 60178
      Phone #: 815-895-3211
      800 #: 800-728-5483
      e-mail: office@ulf.org
      Home page: http://www.ulf.org/
    • Zellweger Baby Support Network
      1852 Iron Horse Loop
      Spearfish SD 57783
      Phone #: 605-642-2072
      800 #: N/A
      e-mail: pamfreeth@zbsn.org
      Home page: http://www.zbsn.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html