Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Castleman's Disease


Synonyms of Castleman's Disease
  • Angiofollicular Lymph Node Hyperplasia
  • Angiomatous Lymphoid
  • Castleman Tumor
  • Giant Benign Lymphoma
  • Giant Lymph Node Hyperplasia
  • Hamartoma of the Lymphatics

Disorder Subdivisions



    General Discussion
    Castleman's disease is a rare disorder characterized by non-cancerous (benign) growths (tumors) that may develop in the lymph node tissue throughout the body (i.e., systemic disease [plasma cell type]). Most often, they occur in the chest, stomach, and/or neck (i.e., localized disease [hyaline-vascular type]). Less common sites include the armpit (axilla), pelvis, and pancreas. Usually the growths represent abnormal enlargement of the lymph nodes normally found in these areas (lymphoid hamartoma). There are two main types of Castleman's disease: hyaline-vascular type and plasma cell type. The hyaline vascular type accounts for approximately 90 percent of the cases. Most individuals exhibit no symptoms of this form of the disorder (asymptomatic) or they may develop non-cancerous growths in the lymph nodes. The plasma cell type of Castleman's disease may be associated with fever, weight loss, skin rash, early destruction of red blood cells, leading to unusually low levels of circulating red blood cells (hemolytic anemia), and/or abnormally increased amounts of certain immune factors in the blood (hypergammaglobulinemia).

    A third type of Castleman's disease has been reported in the medical literature. This type may affect more than one area of the body (multicentric or generalized Castleman's disease). Many individuals with Multicentric Castleman's disease may exhibit an abnormally large liver and spleen (hepatosplenomegaly). Researchers' opinions in the medical literature differ as to whether Multicentric Castleman's disease is a distinct entity or a multicentric form of the plasma cell type of Castleman's disease.
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    Organizations related to Castleman's Disease
    • American Autoimmune Related Diseases Association, Inc.
      22100 Gratiot Avenue
      Eastpointe MI 48021
      Phone #: 586-776-3900
      800 #: 800-598-4668
      e-mail: aarda@aarda.org
      Home page: http://www.aarda.org/
    • American Cancer Society, Inc.
      1599 Clifton Road NE
      Atlanta GA 30329
      Phone #: 404-320-3333
      800 #: 800-227-2345
      e-mail: N/A
      Home page: http://www.cancer.org
    • AutoImmunity Community
      None
      None None None
      Phone #: (91-9) -552-9057
      800 #: N/A
      e-mail: bandrews@autoimmunitycommunity.org
      Home page: http://autoimmunitycommunity.org
    • International Castleman's Disease Organization
      4 Brazos Court
      Santa Fe NM 87508
      Phone #: 505-424-7947
      800 #: N/A
      e-mail: HMConsult@msn.com
      Home page: http://www.castlemans.org
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • NIH/National Heart, Lung and Blood Institute Information Center
      P.O. Box 30105
      Bethesda MD 20824-0105
      Phone #: 301-592-8573
      800 #: --
      e-mail: nhlbiinfo@rover.nhlbi.nih.gov
      Home page: N/A
    • UCSF Hemophilia Treatment Center
      400 Parnassus Ave.
      San Francisco CA 94143
      Phone #: 415-353-2986
      800 #: N/A
      e-mail: N/A
      Home page: http://www.ucsfhealth.org/adult/medical_services/blood/hemophilia/index.html



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html