Diseases & Conditions


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Cicatricial alopecia


Synonyms of Cicatricial alopecia
  • alopecia cicatrisata
  • Brocq pseudopelade
  • pseudopelade
  • scarring hair loss

Disorder Subdivisions



    General Discussion
    Cicatricial alopecia usually includes a range of rare disorders related to the destruction of the hair follicle and gets replaced by scar tissue which may lead to permanent hair loss. Typically the hair loss is gradual, without symptoms, and is unnoticed for long periods. In some the hair loss is also associated with rapidly progressive symptoms such as itching, burning and pain. The inflammation that destroys the follicle is located below the surface of the skin and there is usually no scar seen on the scalp. Affected areas of the scalp may show little signs of inflammation.

    There are two known types of cicatricial alopecias classified as primary Cicatricial alopecias or secondary Cicatricial alopecias. For primary cicatricial alopecias in the hair follicle is the target of the destructive inflammatory process. In secondary cicatricial alopecias, destruction of the hair follicle is an ?accidental? non-follicle-directed process or external injury, such as severe infections, burns, radiation, or tumors.

    Primary cicatricial alopecias are further classified by the type of inflammatory cells that destroy the hair follicle during the active stage of the disease. The inflammation may predominantly involve lymphocytes or neutrophils. Cicatricial alopecias that predominantly involve lymphocytic inflammation include lichen planopilaris, frontal fibrosing alopecia, chronic cutaneous lupus erythematosus, central centrifugal alopecia, pseudopelade (Brocq), alopecia mucinosa, and keratosis follicularis spinulosa decalvans.

    Cicatricial alopecias that are due to predominantly neutrophilic inflammation include folliculitis decalvans and dissecting cellulitis.

    Sometimes the inflammation shifts from a predominantly neutrophilic process to a lymphocytic process. Cicatricial alopecias with a mixed inflammatory infiltrate include folliculitis keloidalis and erosive pustular dermatosis.

    Organizations related to Cicatricial alopecia
    • American Academy of Dermatology
      930 East Woodfield Road
      Schaumburg IL 60173
      Phone #: 847-330-0230
      800 #: 888-462-3376
      e-mail: None.
      Home page: http://www.aad.org
    • Cicatricial Alopecia Research Foundation
      PO Box 64158
      Los Angeles CA 90064
      Phone #: 310-475-2419
      800 #: N/A
      e-mail: info@carfintl.org
      Home page: http://www.carfintl.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html