Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Holoprosencephaly


Synonyms of Holoprosencephaly
  • Alobar Holoprosencephaly
  • Holoprosencephaly Sequence
  • HPE
  • Lobar Holoprosencephaly
  • Middle interhemispheric fusion
  • Semilobar Holoprosencephaly

Disorder Subdivisions



    General Discussion
    Holoprosencephaly (HPE) is the failure of the prosencephalon (a region of the brain in the fetus that develops into parts of the adult brain), or forebrain, to develop normally. Instead of the normal completely distinct left and right halves of the forebrain, there is an abnormal continuity between the two sides. Mental retardation is associated and seizures are often present. Children with holoprosencephaly may also have defects in the development of the middle of the face such as closely set eyes (hypotelorism), tooth abnormalities (single central incisor), cleft lip/palate, and an abnormally small head (microcephaly) may occur.

    Organizations related to Holoprosencephaly
    • Carter Centers for Brain Research in Holoprosencephaly and Related Malformations
      Texas Scottish Rite Hospital for Children
      Dallas TX 75219-9842
      Phone #: 214-559-8411
      800 #: 800-421-1121
      e-mail: hpe@tsrh.org
      Home page: http://www.stanford.edu/group/hpe
    • Independent Holoprosencephaly Support Site
      Web Site on the Internet
      None None None
      Phone #: --
      800 #: --
      e-mail: hpe@att.net
      Home page: http://hpe.home.att.net
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • NIH/National Institute of Child Health and Human Development
      31 Center Dr
      Bethesda MD 20892
      Phone #: 301-496-5133
      800 #: --
      e-mail: N/A
      Home page: http://www.nichd.nih.gov/
    • Society for the Rehabilitation of the Facially Disfigured, Inc.
      550 First Avenue
      New York NY 10016
      Phone #: 212-340-5400
      800 #: --
      e-mail: N/A
      Home page: N/A



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html