Diseases & Conditions


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Hyperlipoproteinemia Type IV


Synonyms of Hyperlipoproteinemia Type IV
  • Carbohydrate-Induced Hyperlipemia
  • Hypercholesterolemia, Type IV
  • Hyperlipidemia IV
  • Hyperprebeta-Lipoproteinemia
  • Hypertriglyceridemia, Endogenous

Disorder Subdivisions



    General Discussion
    Hyperlipoproteinemia Type IV is a not uncommon inherited metabolic disorder that is characterized by increased blood levels of the triglyceride form of fat that makes up very low-density lipids (VLDL). Abnormally high blood levels of triglycerides or cholesterol (another form of blood plasma fat) may be the result of poor dietary habits, genetic causes, or other metabolic disorders or a side effect of certain drugs.

    Hyperlipoproteinemia Type IV is one of a family of five types of hyperlipoproteinemia, which is an indicator of a risk of heart disease. Each of types I through IV presents a different profile of blood fat and a different set of associated risks of heart disease.

    Hyperlipoproteinemia and hyperlipidemia are synonymous. Both refer to an excess of fatty substances (lipids) in the blood. The condition may also be called hyperlipoproteinemia because the fats are transported through the blood as attachments to specialized proteins. These fat-protein complex molecules are called lipoproteins, among which the better known are HDL (high density lipoprotein, LDL (low density lipoprotein), and VLDL (very low density lipoprotein).

    Studies have shown that the risk of heart disease is directly proportional to the blood level of a complex chemical called LDL-cholesterol and inversely proportional to the blood level of HDL-cholesterol. If the blood level of LDL is high, then the risk of heart disease is also high. However, if the blood level of HDL is high, the risk of heart disease is correspondingly low.

    Hyperlipoproteinemia Type IV is common and frequently runs in families; i.e. it is genetic in origin. It is characterized by high blood triglyceride levels and obesity, usually with mild diabetes.

    For a very brief review of each of the other hyperlipoproteinemias. see the Related Disorders section of this report.
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    Organizations related to Hyperlipoproteinemia Type IV
    • American Heart Association
      National Center
      Dallas TX 75231-4596
      Phone #: 214-373-6300
      800 #: 800-242-8721
      e-mail: inquire@heart.org
      Home page: http://www.americanheart.org
    • NIH/National Heart, Lung and Blood Institute Information Center
      P.O. Box 30105
      Bethesda MD 20824-0105
      Phone #: 301-592-8573
      800 #: --
      e-mail: nhlbiinfo@rover.nhlbi.nih.gov
      Home page: N/A



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html