Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Leukocyte Adhesion Deficiency Syndromes


Synonyms of Leukocyte Adhesion Deficiency Syndromes
  • LAD syndromes

Disorder Subdivisions

  • Congenital Disorder of Glycosylation Type II c
  • LAD I
  • LAD II
  • LAD III
  • leukocyte adhesion deficiency type I
  • leukocyte adhesion deficiency type II
  • leukocyte adhesion deficiency type III
  • Rambon-Hasharon syndrome


General Discussion
Leukocyte adhesions deficiency (LAD) syndromes are a group of rare disorders affecting the immune system. LAD syndromes are characterized by defects affecting how white blood cells (leukocytes) respond and travel to the site of a wound or infection. Three distinct types of leukocyte adhesion syndrome have been identified. The specific symptoms and the severity of LAD syndromes vary from one person to another. All affected individuals develop an increased susceptibility to developing recurrent bacterial and fungal infections. Additional symptoms may occur depending upon the specific subtype present. LAD syndromes are caused by mutations of specific genes that contain instructions for creating certain proteins that are necessary for white blood cells to travel from the bloodstream to the site of an infection or inflammation. Individuals with severe forms of LAD may have near complete absence of these proteins. Individuals who have milder forms of LAD syndromes have deficient levels of these proteins, but retain some residual protein activity.

Organizations related to Leukocyte Adhesion Deficiency Syndromes
  • Canadian Immunodeficiencies Patient Organization
    362 Concession 12 East
    Hastings, ONT None K0L 1Y0
    Phone #: 705- 69-6 3679
    800 #: 87-7 2-62 CIPO
    e-mail: info@cipo.ca
    Home page: http://www.cipo.ca
  • European Society for Immunodeficiencies (ESID)
    c/o Dr. Esther de Vries
    Hertogenbosch None 5200 ME's
    Phone #: +31- 73--6992965
    800 #: N/A
    e-mail: info@esid.org
    Home page: http://www.esid.org
  • Immune Deficiency Foundation
    40 West Chesapeake Avenue
    Towson MD 21204
    Phone #: 410-321-6647
    800 #: 800-296-4433
    e-mail: idf@primaryimmune.org
    Home page: http://www.primaryimmune.org
  • International Patient Organization for Primary Immunodeficiencies
    Firside
    Cornwall None PL11 3LE
    Phone #: 44 -150-3 250 668
    800 #: --
    e-mail: info@ipopi.org
    Home page: http://www.ipopi.org/
  • Jeffrey Modell Foundation
    747 Third Ave
    New York NY 10017
    Phone #: 212-819-0200
    800 #: 866-469-6474
    e-mail: info@jmfworld.org
    Home page: http://www.info4pi.org
  • March of Dimes Birth Defects Foundation
    1275 Mamaroneck Avenue
    White Plains NY 10605
    Phone #: 914-428-7100
    800 #: 888-663-4637
    e-mail: Askus@marchofdimes.com
    Home page: http://www.marchofdimes.com
  • NIH/National Institute of Allergy and Infectious Diseases
    6610 Rockledge Drive
    Bethesda MD 20892-6612
    Phone #: 301-496-5717
    800 #: --
    e-mail: N/A
    Home page: http://www.niaid.nih.gov/



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html