Diseases & Conditions


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Membranoproliferative Glomerulonephritis Type II


Synonyms of Membranoproliferative Glomerulonephritis Type II
  • dense deposit disease
  • MPGN type II

Disorder Subdivisions



    General Discussion
    Membranoproliferative glomerulonephritis type II (MPGN2) is one of three related types of a disease of the tiny filtering mechanism (glomeruli) of the kidney. The disease is probably autoimmune, although just what triggers the immune system to generate an autoimmune response is not known.

    The glomeruli are the part of the internal kidney structures where the blood flows through very small capillaries and is filtered through membranes to form urine. When this disease is present, deposits of immune materials spread through the membranes leading to a thickening of the capillary walls, and therefore disrupting the kidney function.

    Levels of some blood proteins related to the immune system (blood complements) are altered in membranoproliferative glomerulonephritis. In particular, levels of some specific complement proteins are very low in the blood. This condition is referred to as ?hypocomplementemia?. In addition, blood may be found in the urine (hematuria), as well as proteins not normally found in urine samples (proteinuria).

    Damage to the glomeruli is progressive, leading in most cases to kidney failure and to long-term kidney dialysis or to kidney transplantation.

    Organizations related to Membranoproliferative Glomerulonephritis Type II
    • Kidneeds Greater Cedar Rapids Foundation
      Greater Cedar Rapids Foundation
      Cedar Rapids IA 52404
      Phone #: N/A
      800 #: --
      e-mail: kidneedsMPGN@yahoo.com
      Home page: http://www.medicine.uiowa.edu/kidneeds
    • National Kidney Foundation
      30 East 33rd Street
      New York NY 10016
      Phone #: 212-889-2210
      800 #: 800-622-9010
      e-mail: info@kidney.org
      Home page: http://www.kidney.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html