Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Nephrogenic Diabetes Insipidus


Synonyms of Nephrogenic Diabetes Insipidus
  • Acquired Nephrogenic Diabetes Insipidus
  • Congenital Nephrogenic Diabetes Insipidus
  • Hereditary Nephrogenic Diabetes Insipidus
  • NDI
  • Vasopressin-Resistant Diabetes Insipidus

Disorder Subdivisions



    General Discussion
    Nephrogenic diabetes insipidus (NDI) is a rare kidney disorder that may be inherited or acquired. NDI is not related to the more common diabetes mellitus (sugar diabetes), in which the body does not produce or properly use insulin. NDI is a distinct disorder caused by complete or partial resistance of the kidneys to arginine vasopressin (AVP). Vasopressin is an antidiuretic hormone used by the kidney to manage water balance in the body. NDI causes chronic excessive thirst (polydipsia), excessive urine production (polyuria), and potentially dehydration. If left untreated, repeated episodes of severe dehydration may develop, eventually resulting in serious complications. Most cases of hereditary NDI are inherited as an X-linked recessive trait. Rare cases are inherited as an autosomal recessive or dominant trait. Two different genes have been identified that cause hereditary NDI.

    NDI may also be acquired during life as a result of drug use (e.g.,lithium therapy), kidney disease, obstruction of the tubes that carry urine from the kidneys to the bladder (ureters), and prolonged metabolic imbalances such as low levels of potassium in the blood (hypokalemia) or low levels of calcium in the blood (hypocalcemia). NDI may also be a complication associated with pregnancy.

    Organizations related to Nephrogenic Diabetes Insipidus
    • Diabetes Insipidus Foundation, Inc.
      5203 New Prospect Court
      Ellicott City MD 21043
      Phone #: 410-480-0880
      800 #: --
      e-mail: info@diabetesinsipidus.org
      Home page: http://www.diabetesinsipidus.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • March of Dimes Birth Defects Foundation
      1275 Mamaroneck Avenue
      White Plains NY 10605
      Phone #: 914-428-7100
      800 #: 888-663-4637
      e-mail: Askus@marchofdimes.com
      Home page: http://www.marchofdimes.com
    • NIH/National Diabetes Information Clearinghouse
      1 Information Way
      Bethesda MD 20892-3560
      Phone #: 301-654-3327
      800 #: 800-891-5388
      e-mail: DDIC@info.niddk.nih.gov
      Home page: http://www.niddk.nih.gov
    • Nephrogenic Diabetes Insipidus Foundation
      PO Box 1390
      Eastsound WA 98245
      Phone #: N/A
      800 #: 888-376-6343
      e-mail: info@ndif.org
      Home page: http://www.ndif.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html