Nephrogenic Diabetes Insipidus / Disease

Diseases & Conditions

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Nephrogenic Diabetes Insipidus

Synonyms of Nephrogenic Diabetes Insipidus

Acquired Nephrogenic Diabetes Insipidus
Congenital Nephrogenic Diabetes Insipidus
Hereditary Nephrogenic Diabetes Insipidus
NDI
Vasopressin-Resistant Diabetes Insipidus

Disorder Subdivisions

General Discussion
Nephrogenic diabetes insipidus (NDI) is a rare kidney disorder that may be inherited or acquired. NDI is not related to the more common diabetes mellitus (sugar diabetes), in which the body does not produce or properly use insulin. NDI is a distinct disorder caused by complete or partial resistance of the kidneys to arginine vasopressin (AVP). Vasopressin is an antidiuretic hormone used by the kidney to manage water balance in the body. NDI causes chronic excessive thirst (polydipsia), excessive urine production (polyuria), and potentially dehydration. If left untreated, repeated episodes of severe dehydration may develop, eventually resulting in serious complications. Most cases of hereditary NDI are inherited as an X-linked recessive trait. Rare cases are inherited as an autosomal recessive or dominant trait. Two different genes have been identified that cause hereditary NDI.

NDI may also be acquired during life as a result of drug use (e.g.,lithium therapy), kidney disease, obstruction of the tubes that carry urine from the kidneys to the bladder (ureters), and prolonged metabolic imbalances such as low levels of potassium in the blood (hypokalemia) or low levels of calcium in the blood (hypocalcemia). NDI may also be a complication associated with pregnancy.

Organizations related to Nephrogenic Diabetes Insipidus

Diabetes Insipidus Foundation, Inc.
5203 New Prospect Court
Ellicott City MD 21043
Phone #: 410-480-0880
800 #: --
e-mail: info@diabetesinsipidus.org
Home page: http://www.diabetesinsipidus.org
MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay WI 54301-1243
Phone #: 920-336-5333
800 #: 877-336-5333
e-mail: mums@netnet.net
Home page: http://www.netnet.net/mums/
Madisons Foundation
PO Box 241956
Los Angeles CA 90024
Phone #: 310-264-0826
800 #: N/A
e-mail: getinfo@madisonsfoundation.org
Home page: http://www.madisonsfoundation.org
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains NY 10605
Phone #: 914-428-7100
800 #: 888-663-4637
e-mail: Askus@marchofdimes.com
Home page: http://www.marchofdimes.com
NIH/National Diabetes Information Clearinghouse
1 Information Way
Bethesda MD 20892-3560
Phone #: 301-654-3327
800 #: 800-891-5388
e-mail: DDIC@info.niddk.nih.gov
Home page: http://www.niddk.nih.gov
Nephrogenic Diabetes Insipidus Foundation
PO Box 1390
Eastsound WA 98245
Phone #: N/A
800 #: 888-376-6343
e-mail: info@ndif.org
Home page: http://www.ndif.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html