Diseases & Conditions


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Polyglucosan Body Disease, Adult


Synonyms of Polyglucosan Body Disease, Adult
  • APBD
  • Polyglucosan Body Disease, Adult Form

Disorder Subdivisions



    General Discussion
    Adult polyglucosan body disease (APBD) is a rare, chronically progressive, metabolic disorder with severe neurological expression. It is caused by the abnormal accumulation of microscopic material (polyglucosan bodies), predominantly within the myelinated nerve fibers (motor neurons). The polyglucosan bodies are spherical and composed of large, complex, sugar-based molecules (branched polysaccharides).

    The disorder typically affects both upper and lower motor neurons, resulting from nerve damage within the brain and spinal cord (central nervous system) respectively. Symptoms usually begin during middle age or later and usually include muscle weakness, loss of sensation, and/or wasting of muscles (atrophy) in the arms and/or legs. Impaired bladder control (neurogenic bladder) and/or mental confusion (dementia) also occur.
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    Organizations related to Polyglucosan Body Disease, Adult
    • APBD Research Foundation
      8 West 37th Street
      New York NY 10018
      Phone #: 212-643-1221
      800 #: N/A
      e-mail: info@APBDRF.org
      Home page: http://www.apbdrf.org
    • Amyotrophic Lateral Sclerosis Association
      27001 Agoura Road
      Calabasas Hills CA 91301-5104
      Phone #: 818-880-9007
      800 #: 800-782-4747
      e-mail: als@alsa-national.org
      Home page: http://www.alsa.org
    • National Institute of Neurological Disorders and Stroke (NINDS)
      31 Center Drive
      Bethesda MD 20892-2540
      Phone #: 301-496-5751
      800 #: 800-352-9424
      e-mail: braininfo@ninds.nih.gov
      Home page: http://www.ninds.nih.gov/



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html