Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Progressive Myoclonus Epilepsy


Synonyms of Progressive Myoclonus Epilepsy
  • Epilepsy, Myoclonic Progressive Familial
  • Myoclonic Epilepsy
  • Myoclonic Progressive Familial Epilepsy
  • Myoclonus Epilepsy
  • Progressive Familial Myoclonic Epilepsy

Disorder Subdivisions

  • Baltic Myoclonus Epilepsy
  • Lafora Body Disease
  • Lafora Disease, Included
  • Lundborg-Unverricht Disease, Included
  • Myoclonic Epilepsy, Hartung Type
  • Unverricht Disease
  • Unverricht-Lundborg Disease


General Discussion
Progressive myoclonus epilepsy (PME) is a group of conditions involving the central nervous system and representing more than a dozen different diseases. These diseases share certain features, including a worsening of symptoms over time and the presence of both muscle contractions (myoclonus) and seizures (epilepsy). Patients may have more than one type of seizure, such as petit mal or grand mal. PME is progressive, but the rate of progression may be quick or slow, depending on the underlying disease.

Progressive myoclonus epilepsy (PME) is different from myoclonic epilepsy. In myoclonic epilepsy, the myoclonic jerking motions occur as part of the seizure. In PME, myoclonus occurs separately from seizures, the two respond differently to the same drugs, they evolve differently during the natural history of the disease, and they cause different problems for the patient. Some drugs that are good for seizures, e.g. phenytoin and carbamazepine, may tend to make the myoclonus worse.

Organizations related to Progressive Myoclonus Epilepsy
  • Epilepsy Canada
    1470 Peel Street
    Quebec None H3A 1T1
    Phone #: 514-845-7855
    800 #: 877-734-0873
    e-mail: epilepsy@epilepsy.ca
    Home page: http://www.epilepsy.ca
  • Epilepsy Foundation
    4351 Garden City Drive
    Landover MD 20785
    Phone #: 301-459-3700
    800 #: 800-332-1000
    e-mail: postmaster@efa.org
    Home page: http://www.epilepsyfoundation.org
  • Madisons Foundation
    PO Box 241956
    Los Angeles CA 90024
    Phone #: 310-264-0826
    800 #: N/A
    e-mail: getinfo@madisonsfoundation.org
    Home page: http://www.madisonsfoundation.org
  • National Institute of Neurological Disorders and Stroke (NINDS)
    31 Center Drive
    Bethesda MD 20892-2540
    Phone #: 301-496-5751
    800 #: 800-352-9424
    e-mail: braininfo@ninds.nih.gov
    Home page: http://www.ninds.nih.gov/
  • National Pediatric Myoclonus Center
    SIU School of Medicine
    Springfield IL 62794-9643
    Phone #: 217-545-7635
    800 #: --
    e-mail: oms@siumed.edu
    Home page: http://www.omsusa.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html