Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Refractory Sprue


Synonyms of Refractory Sprue
  • Intractable Celiac Sprue
  • Refractory Celiac Disease
  • Unclassified Celiac Sprue

Disorder Subdivisions



    General Discussion
    Refractory sprue (RS) is a complex autoimmune disorder much like the more common celiac sprue but, unlike celiac sprue, it is resistant or unresponsive to six months of treatment with a strict gluten-free diet. Gliadin, a component of the wheat storage protein gluten, together with similar proteins in barley and rye, are the villains that trigger the immune reaction in celiac sprue. The diagnosis of RS is made by exclusion, especially of any other disorder that can affect the huge number of thread-like projections that line the interior of the intestine (intestinal villi), such as intestinal lymphoma, Crohn?s disease, or small intestinal bacterial overgrowth.

    The intestinal villi are the means by which the gut absorbs fluids and nutrients. In celiac sprue and refractory sprue, these villi shrink and shrivel (atrophy) affecting the absorption of nutrients via the intestines. In celiac sprue, treatment by means of a strict gluten-free diet is usually sufficient to overcome the disorder. However, refractory sprue is just that: refractory or stubbornly resistant to treatment. Only a small percentage of the people with celiac sprue will develop RS, and these patients are almost invariably 30 years of age or older. However, as yet, it is difficult to predict which patient of those with celiac sprue will develop RS.

    Organizations related to Refractory Sprue
    • American Dietetic Association
      216 West Jackson Boulevard
      Chicago IL 60606-6995
      Phone #: 312-899-0400
      800 #: 800-877-1600
      e-mail: infocenter@eatright.org
      Home page: http://www.eatright.org
    • Association of Gastrointestinal Motility Disorders, Inc. (AGMD)
      AGMD International Corporate Headquarters
      Bedford MA 01730
      Phone #: 781-275-1300
      800 #: --
      e-mail: digestive.motility@gmail.com
      Home page: http://www.agmd-gimotility.org
    • Celiac Disease Foundation
      13251 Ventura Boulevard
      Studio City CA 91604
      Phone #: 818-990-2354
      800 #: --
      e-mail: cdf@celiac.org
      Home page: http://www.celiac.org
    • Celiac Sprue Association/USA, Inc.
      P.O. Box 31700
      Omaha NE 68131-0700
      Phone #: 402-558-0600
      800 #: 877-272-4272
      e-mail: celiacs@csaceliacs.org
      Home page: http://www.csaceliacs.org
    • Crohn's and Colitis Foundation of America
      386 Park Avenue South
      New York NY 10016-9804
      Phone #: 212-685-3440
      800 #: 800-932-2423
      e-mail: info@ccfa.org
      Home page: http://www.ccfa.org
    • Gluten Intolerance Group of North America
      15110 10th Avenue SW
      Seattle WA 98166-1820
      Phone #: 206-246-6652
      800 #: --
      e-mail: info@gluten.net
      Home page: http://www.gluten.net
    • International Foundation for Functional Gastrointestinal Disorders
      P.O. Box 170864
      Milwaukee WI 53217
      Phone #: 414-964-1799
      800 #: 888-964-2001
      e-mail: iffgd@iffgd.org
      Home page: http://www.iffgd.org
    • NIH/National Digestive Diseases Information Clearinghouse
      2 Information Way
      Bethesda MD 20892-3570
      Phone #: 301-654-3810
      800 #: 800-891-5389
      e-mail: nddic@info.niddk.nih.gov
      Home page: http://www.niddk.nih.gov
    • National Foundation for Celiac Awareness
      P.O. Box 544 or 224 South Maple Street
      Ambler PA 19002
      Phone #: 215-325-1306
      800 #: N/A
      e-mail: info@celiaccentral.org
      Home page: http://www.CeliacCentral.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html