Diseases & Conditions


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Rosai-Dorfman Disease


Synonyms of Rosai-Dorfman Disease
  • RDD
  • SHML
  • Sinus Histiocytosis with Massive Lymphadenopathy

Disorder Subdivisions



    General Discussion
    Rosai-Dorfman disease is a rare disorder characterized by over-production (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadenopathy), most often those of the neck (cervical lymphadenopathy). In some cases, abnormal accumulation of histiocytes may occur in other areas of the body besides the lymph nodes (extranodal). These areas include the skin, central nervous system, kidney, and digestive tract. The symptoms and physical findings associated with Rosai-Dorfman disease vary depending upon the specific areas of the body that are affected. The exact cause of Rosai-Dorfman disease is unknown.
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    Organizations related to Rosai-Dorfman Disease
    • Histiocytosis Association of America
      332 North Broadway
      Pitman NJ 08071
      Phone #: 856-589-6606
      800 #: 800-548-2758
      e-mail: association@histio.org
      Home page: http://www.histio.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • NIH/National Heart, Lung and Blood Institute
      31 Center Drive MSC 2480
      Bethesda MD 20892-2480
      Phone #: 301-592-8573
      800 #: --
      e-mail: nhlbiinfo@rover.nhlbi.nih.gov
      Home page: http://www.nhlbi.nih.gov/



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html