Diseases & Conditions


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Susac's Syndrome


Synonyms of Susac's Syndrome
  • Susac syndrome

Disorder Subdivisions



    General Discussion
    Susac?s syndrome is a rare disorder characterized by impaired brain function (encephalopathy), blockage (occlusion) of the arteries that supply blood to the retina (branched retinal arterial occlusion [BRAO]), and hearing loss. Two main forms of Susac?s syndrome have been identified. In one form, encephalopathy is the main finding; in the other form, BRAO and hearing loss occur without signs of brain disease. The specific symptoms and severity of Susac?s syndrome vary from one person to another. The encephalopathic form of Susac?s syndrome often improves spontaneously even without treatment (self-limited); the other form is frequently a chronic disorder. Although considered rare, Susac?s syndrome is being recognized more often worldwide and its true frequency in the general population is unknown.

    Susac?s syndrome is considered an autoimmune endotheliopathy. An autoimmune disorder occurs when the body?s own immune system mistakenly attacks healthy tissue. An endotheliopathy is any disorder that primarily involves the endothelium, which is the thin layer of cells that line the walls of blood vessels. In Susac?s syndrome, the smallest blood vessels (microvasculature) of the circulatory system such as the capillaries, venules and arterioles are affected. Specifically, the microvasculature of the brain, retinas and inner ears are involved.

    Organizations related to Susac's Syndrome
    • American Academy of Audiology
      11730 Plaza America
      Reston VA 20190
      Phone #: 703-790-8466
      800 #: 800-222-2336
      e-mail: info@audiology.org
      Home page: http://www.audiology.org
    • American Autoimmune Related Diseases Association, Inc.
      22100 Gratiot Avenue
      Eastpointe MI 48021
      Phone #: 586-776-3900
      800 #: 800-598-4668
      e-mail: aarda@aarda.org
      Home page: http://www.aarda.org/
    • AutoImmunity Community
      None
      None None None
      Phone #: (91-9) -552-9057
      800 #: N/A
      e-mail: bandrews@autoimmunitycommunity.org
      Home page: http://autoimmunitycommunity.org
    • Better Hearing Institute
      515 King Street, Suite 420
      Alexandria VA 22314
      Phone #: 703-684-3391
      800 #: 800-327-9355
      e-mail: mail@betterhearing.org
      Home page: http://www.betterhearing.org
    • Genetic and Rare Diseases (GARD) Information Center
      PO Box 8126
      Gaithersburg MD 20898-8126
      Phone #: 301-519-3194
      800 #: 888-205-2311
      e-mail: gardinfo@nih.gov
      Home page: http://www.genome.gov/10000409
    • National Institute of Neurological Disorders and Stroke (NINDS)
      31 Center Drive
      Bethesda MD 20892-2540
      Phone #: 301-496-5751
      800 #: 800-352-9424
      e-mail: braininfo@ninds.nih.gov
      Home page: http://www.ninds.nih.gov/



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html