Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Toxic Epidermal Necrolysis


Synonyms of Toxic Epidermal Necrolysis
  • Acute Toxic Epidermolysis
  • Dermatitis Exfoliativa
  • Lyelles Syndrome
  • Lyell Syndrome
  • Ritter Disease
  • Ritter-Lyell Syndrome
  • Scalded Skin Syndrome
  • Staphyloccal Scalded Skin Syndrome
  • TEN
  • Toxic Epidermal Necrolysis

Disorder Subdivisions



    General Discussion
    Toxic epidermal necrolysis (TEN) is a rare, sometimes life-threatening unless properly treated, immunological disorder of the skin. It is characterized by blisters that meld into one another to cover a substantial portion of the body (30% and more), and extensive peeling or sloughing off of skin (exfoliation and denudation). The exposed under layer of skin (dermis) is red and suggests severe scalding. Often, the mucous membranes become involved, especially around the eyes (conjunctivitis), but also the mouth, throat, and bronchial tree.

    Onset can occur at any age. The infantile form frequently follows an infection. In adults the disorder is usually caused by a reaction to taking a pharmaceutical drug, especially anticonvulsants, non-steroid anti-inflammatories, and/or some antibiotics.

    TEN is thought to be an immunological disorder and to be one of a family of three skin disorders. TEN is considered to be the more serious, followed by Stevens-Johnson syndrome and erythema multiforme, in order of severity of disease.

    Organizations related to Toxic Epidermal Necrolysis
    • Dystrophic Epidermolysis Bullosa Research Association of America, Inc. (DEBRA)
      16 East 41st Street
      New York NY 10017
      Phone #: 212-868-1573
      800 #: 866-332-7276
      e-mail: staff@debra.org
      Home page: http://www.debra.org
    • NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
      1 AMS Circle
      Bethesda MD 20892-3675
      Phone #: 301-495-4484
      800 #: 877-226-4267
      e-mail: NIAMSinfo@mail.nih.gov
      Home page: http://www.niams.nih.gov/Health_Info
    • Stevens Johnson Syndrome Foundation and Support Group
      PO Box 350333
      Westminster CO 80035-0333
      Phone #: 303-635-1241
      800 #: --
      e-mail: sjsupport@aol.com
      Home page: http://www.sjsupport.org
    • University of Pennsylvania Dermatology Clinic
      Dermatology Clinic
      Philadelphia PA 19104
      Phone #: 215-662-6535
      800 #: --
      e-mail: N/A
      Home page: N/A



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html