Diseases & Conditions


Alveolar Soft Part Sarcoma

Synonyms of Alveolar Soft Part Sarcoma
  • Alveolar sarcoma of soft parts
  • ASPS
  • ASP sarcoma

Disorder Subdivisions

    General Discussion
    Alveolar soft part sarcoma (ASPS) is a rare sarcoma (malignant tumor of connective tissue) of an unclear cause. It is among the least common sarcomas, representing 0.2-1 percent of large studies of soft tissue sarcomas. Since there are approximately 8000 soft-tissue sarcomas per year that arise in the United States, this means there are on the order of 15 to 80 cases nationwide each year. It is characterized by a painless mass in the leg or buttock, with a particular affinity to travel to the lungs as multiple nodules, presumably while the sarcoma itself is still small. ASPS is very rare, because it involves a specific breaking and joining event between two chromosomes, called an unbalanced translocation. This finding is observed in essentially all ASPS examined so far. This finding cannot be passed on to children, however, as the finding occurs only in the tumor, not in the normal cells; in addition, there are no families in which multiple family members have ASPS.

    Treatment is with surgery and radiation for the primary place where the sarcoma arises. For disease that travels to the lungs, sometimes surgery is possible to remove nodules, but more typically chemotherapy is the only option for treatment. This tumor tends to be resistant to standard chemotherapy, so new treatments involving new chemotherapy drugs are also a reasonable option for treatment. Interferon-alfa showed benefit in one person from Japan with ASPS. There is little other data on possible helpful chemotherapy for this tumor.

    Organizations related to Alveolar Soft Part Sarcoma
    • Alliance Against Alveolar Soft Part Sarcoma
      141-08 Coolidge Ave
      Briarwood NY 11435
      Phone #: 718-523-7752
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.alveolarspsarcoma.net/
    • American Cancer Society, Inc.
      1599 Clifton Road NE
      Atlanta GA 30329
      Phone #: 404-320-3333
      800 #: 800-227-2345
      e-mail: N/A
      Home page: http://www.cancer.org
    • BeatSarcoma
      143 28th Street
      San Francisco CA 94131
      Phone #: 415-651-4473
      800 #: N/A
      e-mail: [email protected]
      Home page: N/A
    • Cancer.Net
      American Society of Clinical Oncology
      Alexandria VA 22314
      Phone #: 571-483-1780
      800 #: 888-651-3038
      e-mail: [email protected]
      Home page: http://www.cancer.net/patient
    • Cure Alveolar Soft Part Sarcoma International
      260 Tappan St.
      Brookline MA 02445
      Phone #: 617-731-1143
      800 #: N/A
      e-mail: [email protected]
      Home page: http://cureasps.org/
    • Friends of Cancer Research
      2231 Crystal Drive
      Arlington VA 22202
      Phone #: 703-302-1503
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.focr.org
    • Lance Armstrong Foundation
      PO Box 161550
      Austin TX 78716-1150
      Phone #: 512-236-8820
      800 #: 866-235-7205
      e-mail: N/A
      Home page: http://www.livestrong.org
    • National Cancer Institute
      6116 Executive Blvd, MSC 8322, Room 3036A
      Bethesda MD 20892-8322
      Phone #: 301-435-3848
      800 #: 800-422-6237
      e-mail: N/A
      Home page: http://www.cancer.gov
    • National Coalition for Cancer Survivorship
      1010 Wayne Avenue
      Silver Spring MD 20910-5600
      Phone #: 301-650-9127
      800 #: 877-622-7937
      e-mail: [email protected]
      Home page: http://
    • Rare Cancer Alliance
      1649 North Pacana Way
      Green Valley AZ 85614
      Phone #: 520-625-5495
      800 #: --
      e-mail: [email protected]
      Home page: http://www.rare-cancer.org
    • Sarcoma Alliance
      775 E. Blithedale #334
      Mill Valley CA 94941
      Phone #: 415-381-7236
      800 #: --
      e-mail: [email protected]
      Home page: http://www.sarcomaalliance.org
    • Sarcoma Foundation of America
      9884 Main Street
      Damascus MD 20872
      Phone #: 301-253-8687
      800 #: --
      e-mail: [email protected]
      Home page: http://www.curesarcoma.org
    • Wellness Community
      919 18th Street N.W.
      Washington DC 20006
      Phone #: 202-659-9709
      800 #: 888-793-9355
      e-mail: [email protected]
      Home page: http://www.thewellnesscommunity.org

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html