Diseases & Conditions



Synonyms of Amyloidosis

    Disorder Subdivisions

    • Hereditary Amyloidosis
    • Localized Amyloidosis
    • Primary Amyloidosis
    • Secondary Amyloidosis

    General Discussion
    Amyloidosis is a group of disorders caused by abnormal folding of proteins leading to fibril formation in one or more body organs, systems or soft tissues. These clumps of protein are called amyloid deposits and the accumulation of amyloid deposits causes the progressive malfunction and eventual failure of the affected organ. Normally, proteins are broken down at about the same rate as they are produced, but these unusually stable amyloid deposits are deposited more rapidly than they can be broken down. The accumulation may be localized in one organ or may be systemic such that several organs are affected.

    The different types of systemic amyloidosis are sometimes classified as primary, secondary or hereditary. Primary amyloidosis (also called AL) is the most common type of systemic amyloidosis. It is caused by an abnormal plasma cell in the bone marrow and sometimes occurs with multiple myeloma. Secondary amyloidosis (also called AA) occurs in association with another disease such as rheumatoid arthritis, familial Mediterranean fever or other chronic infection or inflammatory disease. Hereditary amyloidosis is a rare type of amyloidosis that is caused by an abnormal gene. There are several abnormal genes that can cause hereditary amyloidosis, but the most common type of hereditary amyloidosis is called ATTR and caused by a mutations in the TTR gene.

    Beta2-microglobulin amyloidosis (A?2M) is a type of systemic amyloidosis that can occur in patients who have experienced long-term kidney dialysis to remove accumulated impurities or wastes in the blood by mechanical filtration.

    Organizations related to Amyloidosis
    • Amyloidosis Australia, Inc.
      17 Victoria Street
      Victoria None 3156
      Phone #: (+6-1)0-3 9758 2172
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.amyloidosisaustralia.org
    • Amyloidosis Foundation
      7151 N. Main St.
      Clarkston MI 48346
      Phone #: 248-922-9610
      800 #: 877-269-5643
      e-mail: [email protected]
      Home page: http://www.amyloidosis.org
    • Amyloidosis Support Groups, Inc
      232 Orchard Drive
      Wood Dale IL 60191
      Phone #: 708-987-7711
      800 #: 866-404-7539
      e-mail: [email protected]
      Home page: http://www.amyloidosissupport.com
    • Association Fransaise Contre l'amylose
      66, rue Saint Jacques
      Marseille Intl 13006
      Phone #: 04 -42 -94 90 86
      800 #: --
      e-mail: N/A
      Home page: http://www.amylose.asso.fr
    • Cancer.Net
      American Society of Clinical Oncology
      Alexandria VA 22314
      Phone #: 571-483-1780
      800 #: 888-651-3038
      e-mail: [email protected]
      Home page: http://www.cancer.net/patient
    • Jack Miller Center for Peripheral Neuropathy
      University of Chicago
      Chicago IL 60637
      Phone #: 773-702-5800
      800 #: N/A
      e-mail: [email protected]
      Home page: http://millercenter.uchicago.edu
    • Kidney & Urology Foundation of America, Inc.
      152 Madison Ave.
      New York NY 10016
      Phone #: 212-629-9770
      800 #: 800-633-6628
      e-mail: [email protected]
      Home page: http://www.kidneyurology.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: [email protected]
      Home page: http://www.netnet.net/mums/
    • March of Dimes Birth Defects Foundation
      1275 Mamaroneck Avenue
      White Plains NY 10605
      Phone #: 914-428-7100
      800 #: 888-663-4637
      e-mail: [email protected]
      Home page: http://www.marchofdimes.com
    • NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
      1 AMS Circle
      Bethesda MD 20892-3675
      Phone #: 301-495-4484
      800 #: 877-226-4267
      e-mail: [email protected]
      Home page: http://www.niams.nih.gov/Health_Info
    • UCSF Hemophilia Treatment Center
      400 Parnassus Ave.
      San Francisco CA 94143
      Phone #: 415-353-2986
      800 #: N/A
      e-mail: N/A
      Home page: http://www.ucsfhealth.org/adult/medical_services/blood/hemophilia/index.html

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html