Familial Cold Autoinflammatory Syndrome / Disease

Diseases & Conditions

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Familial Cold Autoinflammatory Syndrome

Synonyms of Familial Cold Autoinflammatory Syndrome

Familial cold urticaria
FCAS

Disorder Subdivisions

General Discussion
Familial cold autoinflammatory syndrome (FCAS), also known as familial cold urticaria, is a rare, inherited inflammatory disorder characterized by intermittent episodes of rash, fever, joint pain and other signs/symptoms of systemic inflammation triggered by exposure to cold. Onset of FCAS occurs during infancy and early childhood and persists throughout the patient's life.

FCAS is one of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. These syndromes are characterized by fever, rash, and joint pain.

FCAS shares symptoms, and should not be confused, with acquired cold urticaria, a more common condition mediated by different mechanisms that usually develops later in life and is rarely inherited.

Organizations related to Familial Cold Autoinflammatory Syndrome

Madisons Foundation
PO Box 241956
Los Angeles CA 90024
Phone #: 310-264-0826
800 #: N/A
e-mail: [email protected]
Home page: http://www.madisonsfoundation.org
NIH/Office of Rare Diseases
Steve Groft, Pharm.D.
Bethesda MD 20892-
Phone #: 301-402-4336
800 #: --
e-mail: [email protected]
Home page: http://www.rarediseases.info.nih.gov/ord/
NOMID Alliance, Inc.
P.O. Box 590354
San Francisco CA 94159
Phone #: 415-831-8782
800 #: N/A
e-mail: [email protected]
Home page: http://www.nomidalliance.net

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html