Diseases & Conditions


Gastroesophageal Reflux

Gastroesophageal reflux is the backward movement of food and acid from the stomach into the esophagus and sometimes into the mouth (see Peptic Disorders: Gastroesophageal Reflux (GERD) ).

Reflux may be caused by the infant's position during feeding; overfeeding; exposure to caffeine, nicotine Some Trade Names NICORETTE NICOTROL , and cigarette smoke; a food intolerance or allergy; or an abnormality of the digestive tract. Symptoms include vomiting, excessive spitting up, damage to the esophagus (the tube that connects the throat to the stomach), and feeding or breathing problems. Tests that help doctors diagnose the condition include a barium study, an esophageal pH probe, a gastric emptying scan, and endoscopy. Treatment options include thickened formula for feedings, special positioning, frequent burping, histamine-2 (H 2 ) blockers, proton pump inhibitors, and, in certain cases, metoclopramide Some Trade Names REGLAN and surgery.

Nearly all infants have episodes of gastroesophageal reflux, which are characterized by wet burps, burping up, or spit up. These wet burps typically occur shortly after eating and are considered normal. Gastroesophageal reflux becomes a concern when it Interferes with feeding and growth Damages the esophagus (esophagitis) Leads to breathing difficulties (such as coughing, wheezing, or stopping breathing) Continues beyond infancy into childhood


Healthy infants have reflux for many reasons. The circular band of muscle at the junction of the esophagus and stomach (the lower esophageal sphincter) normally keeps stomach contents from entering the esophagus. In infants, this muscle may be underdeveloped, or it may relax at inappropriate times, allowing stomach contents to move backward (reflux) into the esophagus. Being held flat during feeding or lying down after feeding promotes reflux because gravity is no longer able to help keep material in the stomach from flowing back up the esophagus. Overfeeding and drinking carbonated beverages predispose to reflux by increasing pressure in the stomach. Cigarette smoke (as secondhand smoke) and caffeine (in beverages or breast milk) relax the lower esophageal sphincter, allowing reflux to occur more readily. Caffeine and nicotine (in breast milk) also stimulate acid production so any reflux that does occur is more acidic. A food allergy or intolerance also can contribute to reflux, but this is a less common cause.

Anatomic abnormalities, such as narrowing of the esophagus, partial blocking of the stomach (pyloric stenosis), or abnormal positioning of the intestines (malrotation), can initially mimic reflux. However, these abnormalities are more serious and can progress to vomiting and other symptoms of obstruction, such as abdominal pain, listlessness, and dehydration.


The most obvious symptoms of gastroesophageal reflux in infants are vomiting and excessive spitting up. Reflux typically worsens in the first several months of life, peaks around 6 to 7 months of age, and then gradually lessens. Nearly all infants with reflux outgrow it by about 18 months of age. In some, however, reflux causes complications and becomes known as gastroesophageal reflux disease (GERD). Such complications include irritability due to stomach discomfort, feeding problems that can result in poor growth, and “spells” of twisting and posturing that may be confused with seizures. Less commonly, small amounts of acid from the stomach may enter the windpipe (aspiration). Acid in the windpipe and breathing passages may result in coughing, wheezing, stopping breathing (apnea), or pneumonia. Many children with asthma also have reflux. Ear pain, hoarseness, hiccups, and sinusitis also can occur as a result of GERD. If the esophagus is significantly irritated (esophagitis), there may be some bleeding, resulting in iron deficiency anemia. In others, esophagitis can cause scar tissue, which can narrow the esophagus (stricture). Heartburn, a common symptom among adolescents and adults with GERD, is more commonly expressed as chest pain or abdominal pain among young children.


Tests are often not needed to diagnose gastroesophageal reflux in infants who simply have mild symptoms such as frequent spit-ups. However, if symptoms are more complicated, various tests can be performed.

A barium study (see Symptoms and Diagnosis of Digestive Disorders: X-ray Studies ) is the most common test. The child swallows barium, a liquid that outlines the digestive tract when x-rays are taken. This test can confirm the diagnosis of gastroesophageal reflux and also help the doctor identify some of the possible causes.

An esophageal pH probe is a thin flexible tube with a sensor at the tip that measures the degree of acidity (pH). Doctors pass the tube through the child's nose, down the throat, and into the end of the esophagus. The tube is usually left in place for 24 hours. Normally, children do not have acid in their esophagus, so if the sensor detects acid, it is a sign of reflux. Doctors sometimes use this test to see whether children with symptoms such as coughing or breathing difficulties have reflux.

In a gastric emptying scan (milk scan), the child drinks a beverage that contains a small amount of mildly radioactive material. This material is harmless to the child. A special camera or scanner that is highly sensitive to radiation can detect where the material is in the child's body. The camera can see how rapidly the material leaves the stomach and whether there is reflux, aspiration, or both.

In upper endoscopy (see Symptoms and Diagnosis of Digestive Disorders: Endoscopy ), the child is sedated, and a small flexible tube with a camera on the end (endoscope) is passed through the mouth into the esophagus and stomach. Doctors may perform upper endoscopy if they need to see whether there is an ulcer or irritation or if they need to obtain a sample for a biopsy. Bronchoscopy (see Symptoms and Diagnosis of Digestive Disorders: Endoscopy ) is a similar test in which doctors use an endoscope to examine the voice box (larynx) and airways. Bronchoscopy can help doctors decide whether reflux is a likely cause of lung or breathing problems.


Treatment of reflux depends on the child's age and symptoms.

For infants who just have wet burps, doctors may recommend no treatment or may suggest measures such as thickening formula for feedings, special positioning, and frequent burping. Formula can be thickened by adding 1 to 3 teaspoons of rice cereal per ounce of formula. The nipple may have to be cross-cut to allow the formula to flow. Infants with reflux should be fed in an upright or semi-upright position and then maintained in an upright position for 30 minutes after eating.

For older children, the head of the bed can be elevated 6 inches (about 15 1 / 4 centimeters) to help reduce nighttime reflux. Older children also should avoid eating 2 to 3 hours before bedtime, drinking carbonated beverages or those that contain caffeine, taking certain drugs (such as those with anticholinergic effects), eating certain foods (such as chocolate), and overeating. All children should be kept away from tobacco smoke.

Drugs: If changes in feeding and positioning do not control symptoms, doctors may prescribe drugs. Several types of drugs are available for reflux: Those that neutralize acid Those that suppress acid production Those that improve the movement of the digestive tract

Antacids are drugs that neutralize gastric acid. These drugs work quickly to relieve symptoms such as heartburn.

For those with more severe disease, acid-suppressing drugs are required. By reducing stomach acid, these drugs lessen symptoms and allow the esophagus to heal. There are two types of acid-suppressing drugs, histamine-2 (H 2 ) blockers and proton pump inhibitors (PPIs). H 2 blockers do not suppress acid production quite as much as PPIs.

Promotility drugs stimulate the movement of contents through the esophagus, stomach, and intestines. These drugs (such as metoclopramide Some Trade Names REGLAN ) may help increase the strength of the lower esophageal sphincter and increase the speed at which the stomach empties. Improved gastric emptying should decrease gastric pressure, making reflux less likely to occur. Doctors used to prescribe these drugs frequently for reflux but now think they are helpful only for certain children.

Surgery: Rarely, reflux does not respond to nonsurgical treatment and is so severe that doctors recommend surgery. The most common surgical procedure is a fundoplication. In fundoplication, the surgeon wraps the top of the stomach around the lower end of the esophagus to make that junction tighter and decrease reflux.

Last full review/revision December 2007 by William J. Cochran, MD

Source: The Merck Manual Home Edition