Diseases & Conditions


Mantle Cell Lymphoma

Synonyms of Mantle Cell Lymphoma
  • No synonyms found

Disorder Subdivisions

  • No synonyms found

General Discussion
Mantle cell lymphoma (MCL) belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system (lymphomas). Functioning as part of the immune system, the lymphatic system helps to protect the body against infection and disease. It consists of a network of tubular channels (lymph vessels) that drain a thin watery fluid known as lymph from different areas of the body into the bloodstream. Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes.

As lymph moves through the lymphatic system, it is filtered by a network of small structures known as lymph nodes that help to remove microorganisms (e.g., viruses, bacteria, etc.) and other foreign bodies. Groups of lymph nodes are located throughout the body, including in the neck, under the arms (axillae), at the elbows, and in the chest, abdomen, and groin. Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. In addition to the lymph nodes, the lymphatic system includes the spleen, which filters worn-out red blood cells and produces lymphocytes, and the tonsils, which are masses of lymphoid tissue in the throat region that help to fight infection. Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. There are two main types of lymphocytes: B-lymphocytes, which may produce specific antibodies to neutralize certain invading microorganisms, and T-lymphocytes, which may directly destroy microorganisms or assist in the activities of other lymphocytes.

Mantle cell lymphoma and other cancers of the lymphatic system (lymphomas) result from errors in the production of a lymphocyte or transformation of a lymphocyte into a malignant cell. Abnormal, uncontrolled growth and multiplication (proliferation) of malignant lymphocytes may lead to enlargement of a specific lymph node region or regions; involvement of other lymphatic tissues, such as the spleen and bone marrow; and spread to other bodily tissues and organs, potentially resulting in life-threatening complications. The specific symptoms and physical findings may vary from case to case, depending upon the extent and region(s) of involvement and other factors.

Non-Hodgkin's lymphomas (NHLs) may be broadly classified into lymphomas that arise from abnormal B-lymphocytes (B-cell lymphomas) and those derived from abnormal T-lymphocytes (T-cell lymphomas). Mantle cell lymphoma (MCL) is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. NHLs may also be categorized based upon certain characteristics of the cancer cells as seen under a microscope and how quickly they may tend to grow and spread. For example, NHLs may be characterized as low-grade (or indolent) lymphomas, which tend to grow slowly and result in few associated symptoms, or intermediate- or high-grade (aggressive) lymphomas, which typically grow rapidly, requiring prompt treatment. There is some debate concerning whether MCL should be categorized as a slow-growing (indolent) or rapidly-growing (aggressive) lymphoma. Although experts have classified MCL as an aggressive lymphoma, it has been shown to have certain characteristics of indolent lymphoma.

According to various estimates, MCL represents approximately 2 to 7 percent of adult NHLs in the United States and Europe. It primarily affects men over the age of 50 years. Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract.

Organizations related to Mantle Cell Lymphoma
  • American Cancer Society, Inc.
    1599 Clifton Road NE
    Atlanta GA 30329
    Phone #: 404-320-3333
    800 #: 800-227-2345
    e-mail: N/A
    Home page: http://www.cancer.org
  • Association of Community Cancer Centers
    11600 Nebel Street
    Rockville MD 20852
    Phone #: 301-984-9496
    800 #: --
    e-mail: N/A
    Home page: http://www.accc-cancer.org
  • Canadian Cancer Society
    10 Alcorn Avenue
    Toronto None M4V 3B1
    Phone #: (41-6) -961-7223
    800 #: (88-8) -939-3333
    e-mail: [email protected]
    Home page: http://www.cancer.ca/
  • Cancer Hope Network
    2 North Road
    Chester NJ 07930
    Phone #: 908-879-4039
    800 #: 877-467-3638
    e-mail: [email protected]
    Home page: http://www.cancerhopenetwork.org
  • Friends of Cancer Research
    2231 Crystal Drive
    Arlington VA 22202
    Phone #: 703-302-1503
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.focr.org
  • International Cancer Alliance for Research and Education
    4853 Cordell Avenue
    Bethesda MD 20814
    Phone #: 301-656-3461
    800 #: 800-422-7361
    e-mail: [email protected]
    Home page: http://www.icare.org
  • Lance Armstrong Foundation
    PO Box 161550
    Austin TX 78716-1150
    Phone #: 512-236-8820
    800 #: 866-235-7205
    e-mail: N/A
    Home page: http://www.livestrong.org
  • Leukemia & Lymphoma Society
    1311 Mamaroneck Ave
    White Plains NY 10605
    Phone #: 914-949-5213
    800 #: 800-955-4572
    e-mail: [email protected]
    Home page: http://www.LLS.org
  • Lymphoma Association (UK)
    PO Box 386
    Bucks Intl HP20 2GA
    Phone #: 012-96 -619400
    800 #: --
    e-mail: lymphoma.org.uk
    Home page: http://www.lymphoma.org.uk
  • Lymphoma Foundation Canada
    16-1375 Southdown Road
    Ontario None L5J 2Z1
    Phone #: (90-5) -822-5135
    800 #: 866-) 6-59-5556
    e-mail: [email protected]
    Home page: http://www.lymphoma.ca
  • Lymphoma Research Foundation
    111 Broadway
    New York NY 10006
    Phone #: 212-349-2910
    800 #: 800-235-6848
    e-mail: [email protected]
    Home page: http://www.lymphoma.org
  • National Cancer Institute
    6116 Executive Blvd, MSC 8322, Room 3036A
    Bethesda MD 20892-8322
    Phone #: 301-435-3848
    800 #: 800-422-6237
    e-mail: N/A
    Home page: http://www.cancer.gov
  • National Cancer Institute Physician Data Query (PDQ) Cancer Information Service
    9000 Rockville Pike
    Bethesda MD 20892
    Phone #: --
    800 #: 800-422-6237
    e-mail: N/A
    Home page: http://www.cancernet.nci.nih.gov/pdq.html
  • National Coalition for Cancer Survivorship
    1010 Wayne Avenue
    Silver Spring MD 20910-5600
    Phone #: 301-650-9127
    800 #: 877-622-7937
    e-mail: [email protected]
    Home page: http://
  • OncoLink: The University of Pennsylvania Cancer Center Resource
    3400 Spruce Street
    Philadelphia PA 19104-4283
    Phone #: 215-349-5445
    800 #: --
    e-mail: [email protected]
    Home page: http://www.oncolink.upenn.edu
  • Rare Cancer Alliance
    1649 North Pacana Way
    Green Valley AZ 85614
    Phone #: 520-625-5495
    800 #: --
    e-mail: [email protected]
    Home page: http://www.rare-cancer.org
  • UCSF Hemophilia Treatment Center
    400 Parnassus Ave.
    San Francisco CA 94143
    Phone #: 415-353-2986
    800 #: N/A
    e-mail: N/A
    Home page: http://www.ucsfhealth.org/adult/medical_services/blood/hemophilia/index.html
  • Wellness Community
    919 18th Street N.W.
    Washington DC 20006
    Phone #: 202-659-9709
    800 #: 888-793-9355
    e-mail: [email protected]
    Home page: http://www.thewellnesscommunity.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html