Diseases & Conditions


Multiple Sclerosis

Synonyms of Multiple Sclerosis
  • Demyelinating Disease
  • Disseminated Sclerosis
  • MS
  • Primary Progressive Multiple Sclerosis
  • Relapsing-Remitting Multiple Sclerosis

Disorder Subdivisions

    General Discussion
    Multiple sclerosis is a chronic neuroimmunologic (both the nervous system and the immunological system are involved) disorder of the central nervous system involving the brain, spinal chord and optic nerves. By means of a mechanism not clearly understood, the protective fatty, insulating substance called myelin sheath that covers the nerve is destroyed. The inflammatory attacks that produce the characteristic scarring (plaques or patches) of the myelin sheath occur randomly, vary in intensity, and at multiple sites. The course of the disease may advance, relapse, remit, or stabilize. The randomness of the location of plaques or patches affects the nerve?s ability to transmit information (neurotransmission) and causes a wide range of neurological symptoms, which may vary from person to person.

    Recently it has been learned that the nerve fibers themselves, (axons), in addition to the myelin sheaths, are affected by the neuroimmunologic attacks. Damage to the nerve cells may be irreversible. As a result, clinicians recommend early intervention with one of the disease-modifying agents (see below).

    Organizations related to Multiple Sclerosis
    • American Association of Neurological Surgeons
      5550 Meadowbrook Drive
      Rolling Meadows IL 60008-3852
      Phone #: 847-378-0500
      800 #: 888-566-2267
      e-mail: [email protected]
      Home page: http://www.NeurosurgeryToday.org
    • American Autoimmune Related Diseases Association, Inc.
      22100 Gratiot Avenue
      Eastpointe MI 48021
      Phone #: 586-776-3900
      800 #: 800-598-4668
      e-mail: [email protected]
      Home page: http://www.aarda.org/
    • AutoImmunity Community
      None None None
      Phone #: (91-9) -552-9057
      800 #: N/A
      e-mail: [email protected]
      Home page: http://autoimmunitycommunity.org
    • Autoimmune Information Network, Inc
      PO Box 4121
      Brick NJ 08723
      Phone #: 732-664-9259
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.aininc.org
    • Christopher Reeve Paralysis Foundation
      500 Morris Ave
      Springfield NJ 07081
      Phone #: 973-379-2690
      800 #: 800-225-0292
      e-mail: [email protected]
      Home page: http://www.crpf.org,
    • Consortium of Multiple Sclerosis Centers
      c/o Gimbel MS Center
      Teaneck NJ 07666
      Phone #: 201-837-0727
      800 #: --
      e-mail: [email protected]
      Home page: http://www.mscare.org
    • European Society for Immunodeficiencies (ESID)
      c/o Dr. Esther de Vries
      Hertogenbosch None 5200 ME's
      Phone #: +31- 73--6992965
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.esid.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: [email protected]
      Home page: http://www.netnet.net/mums/
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.madisonsfoundation.org
    • Multiple Sclerosis Association of America
      706 Haddonfield Road
      Cherry Hill NJ 08002
      Phone #: --
      800 #: 800-532-7667
      e-mail: [email protected]
      Home page: http://www.msaa.com
    • Multiple Sclerosis Foundation
      6350 N. Andrews Ave.
      Ft. Lauderdale FL 33309-2130
      Phone #: 954-776-6805
      800 #: 888-673-6287
      e-mail: [email protected]
      Home page: http://www.msfocus.org
    • Multiple Sclerosis International Federation
      3rd Floor Skyline House
      London Intl SE1 0LX
      Phone #: +44- (0-)20 7620 1911
      800 #: --
      e-mail: [email protected]
      Home page: http://www.msif.org
    • National Institute of Neurological Disorders and Stroke (NINDS)
      31 Center Drive
      Bethesda MD 20892-2540
      Phone #: 301-496-5751
      800 #: 800-352-9424
      e-mail: [email protected]
      Home page: http://www.ninds.nih.gov/
    • National Multiple Sclerosis Society
      1100 New York Avenue NW
      Washington DC 20005
      Phone #: 202-408-1500
      800 #: 800-344-4867
      e-mail: [email protected]
      Home page: http://www.nationalmssociety.org
    • New Horizons Un-Limited, Inc.
      811 East Wisconsin Ave
      Milwaukee WI 53202
      Phone #: 414-299-0124
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.new-horizons.org
    • PLAN Institute for Caring Citizenship
      260-3665 Kingsway
      British Columbia None V5R 5W2
      Phone #: 604--43-9-9566
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.planinstitute.ca/?q=learnfromus/library
    • Spastic Paraplegia Foundation
      11 Douglass Green
      Woburn MA 01801
      Phone #: N/A
      800 #: 877-773-4483
      e-mail: [email protected]
      Home page: http://sp-foundation.org
    • Stem Cell Research Foundation
      22512 Gateway Center Drive
      Clarksburg MD 20871
      Phone #: 877-842-3442
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.stemcellresearchfoundation.org
    • Vasculitis of the Central Nervous System
      [email protected]
      None None None
      Phone #: 770-978-5636
      800 #: --
      e-mail: [email protected]
      Home page: http://[email protected]
    • WE MOVE (Worldwide Education and Awareness for Movement Disorders)
      204 West 84th Street
      New York NY 10024
      Phone #: 212-875-8312
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.wemove.org

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html