Diseases & Conditions


Myeloma, Multiple

Synonyms of Myeloma, Multiple
  • Kahler Disease
  • Myelomatosis
  • Plasma Cell Myeloma

Disorder Subdivisions

  • Extramedullary Plasmacytoma
  • Nonsecretory Myeloma
  • Osteosclerotic Myeloma
  • Plasma Cell Leukemia
  • Smoldering Myeloma
  • Solitary Plasmacytoma of Bone

General Discussion
Multiple myeloma is a rare form of cancer characterized by excessive production (proliferation) and improper function of certain cells (plasma cells) found in the bone marrow. Plasma cells, which are a type of white blood cell, are produced in the bone marrow and eventually enter the bloodstream. Excessive plasma cells may eventually mass together to form a tumor or tumors in various sites of the body, especially the bone marrow. If only a single tumor is present, the term solitary plasmocytoma is used. When multiple tumors are present, the term multiple myeloma is used. Plasma cells are a key component of the immune system and secrete a substance known as myeloma proteins (M-proteins), a type of antibody. Antibodies are special proteins that the body produces to combat invading microorganisms, toxins, or other foreign substances. Overproduction of plasma cells in affected individuals results in abnormally high levels of these proteins within the body.

Major symptoms of multiple myeloma may include bone pain, especially in the back and the ribs; low levels of circulating red blood cells (anemia) resulting in weakness, fatigue, and lack of color (pallor); and kidney (renal) abnormalities. In most cases, affected individuals are more susceptible to bacterial infections such as pneumonia. The exact cause of multiple myeloma is unknown.

Organizations related to Myeloma, Multiple
  • American Cancer Society, Inc.
    1599 Clifton Road NE
    Atlanta GA 30329
    Phone #: 404-320-3333
    800 #: 800-227-2345
    e-mail: N/A
    Home page: http://www.cancer.org
  • Cancer Research UK
    PO Box 123
    London Intl WC2A 3PX
    Phone #: 020--72-42 0200
    800 #: N/A
    e-mail: N/A
    Home page: http://www.imperialcancer.co.uk
  • Cancer.Net
    American Society of Clinical Oncology
    Alexandria VA 22314
    Phone #: 571-483-1780
    800 #: 888-651-3038
    e-mail: [email protected]
    Home page: http://www.cancer.net/patient
  • Friends of Cancer Research
    2231 Crystal Drive
    Arlington VA 22202
    Phone #: 703-302-1503
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.focr.org
  • International Myeloma Foundation
    12650 Riverside Dr
    North Hollywood CA 91607
    Phone #: 818-487-7455
    800 #: 800-452-2873
    e-mail: [email protected]
    Home page: http://www.myeloma.org
  • Lance Armstrong Foundation
    PO Box 161550
    Austin TX 78716-1150
    Phone #: 512-236-8820
    800 #: 866-235-7205
    e-mail: N/A
    Home page: http://www.livestrong.org
  • Leukemia & Lymphoma Society
    1311 Mamaroneck Ave
    White Plains NY 10605
    Phone #: 914-949-5213
    800 #: 800-955-4572
    e-mail: [email protected]
    Home page: http://www.LLS.org
  • Multiple Myeloma Research Foundation
    51 Locust Avenue
    New Canaan CT 06840
    Phone #: 203-972-1520
    800 #: --
    e-mail: [email protected]
    Home page: http://www.multiplemyeloma.org
  • NIH/Hematology Branch, National Heart, Lung and Blood Institute (NHLBI)
    10 Center Dr, Building 10-CRC
    Bethesda MD 20892-1202
    Phone #: 301-402-0764
    800 #: --
    e-mail: [email protected]
    Home page: http://dir.nhlbi.nih.gov/labs/hb/index.asp?
  • National Cancer Institute
    6116 Executive Blvd, MSC 8322, Room 3036A
    Bethesda MD 20892-8322
    Phone #: 301-435-3848
    800 #: 800-422-6237
    e-mail: N/A
    Home page: http://www.cancer.gov
  • Patient Registries at Slone: Myeloma & MDS
    Slone Epidemiology Center at Boston University
    Boston MA 02215
    Phone #: 617-734-6006
    800 #: 800-231-3769
    e-mail: [email protected]
    Home page: http://www.bu.edu/prs
  • UCSF Hemophilia Treatment Center
    400 Parnassus Ave.
    San Francisco CA 94143
    Phone #: 415-353-2986
    800 #: N/A
    e-mail: N/A
    Home page: http://www.ucsfhealth.org/adult/medical_services/blood/hemophilia/index.html
  • Wellness Community
    919 18th Street N.W.
    Washington DC 20006
    Phone #: 202-659-9709
    800 #: 888-793-9355
    e-mail: [email protected]
    Home page: http://www.thewellnesscommunity.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html