Diseases & Conditions


Paget's Disease of the Breast

Synonyms of Paget's Disease of the Breast
  • Mammary Paget's Disease
  • Paget's Disease of the Nipple
  • Paget's Disease of the Nipple and Areola

Disorder Subdivisions

    General Discussion
    Paget's disease of the breast is a rare form of breast cancer that almost exclusively occurs in women. However, rare cases have been recorded in which men have been affected. The condition was originally reported in 1874 by Sir James Paget, an English surgeon, who also described an unrelated skeletal condition known as Paget's disease of the bone. It is essential to note that these disorders are distinct disease entities that are medically unrelated.

    Paget's disease of the breast is characterized by inflammatory, eczema-like changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple. In those with Paget's disease of the breast, distinctive tumor cells (known as Paget cells) are present within the outermost layer of skin (epidermis) of the nipple. In addition, the condition is often associated with an underlying malignancy (i.e., cancer) of the milk ducts (ductal carcinoma). The malignancy may be confined to cells lining the milk ducts (carcinoma in situ) or may have invaded surrounding tissue (infiltrating carcinoma). (The milk ducts [lactiferous ducts] are the channels that carry milk secreted by lobes of the breast to the nipple.) Paget's disease of the breast is thought to represent approximately two to four percent of breast cancers.

    Organizations related to Paget's Disease of the Breast
    • American Cancer Society, Inc.
      1599 Clifton Road NE
      Atlanta GA 30329
      Phone #: 404-320-3333
      800 #: 800-227-2345
      e-mail: N/A
      Home page: http://www.cancer.org
    • Breast Cancer Advisory Center
      P.O. Box 334
      Kensington MD 20895
      Phone #: --
      800 #: --
      e-mail: N/A
      Home page: N/A
    • Breast Cancer Society of Canada
      401 St. Clair Street
      Ontario None N7V 1P2
      Phone #: 519-336-0746
      800 #: --
      e-mail: [email protected]
      Home page: http://www.bcsc.ca
    • Canadian Breast Cancer Network
      331 rue Cooper Street
      Ontario Intl K2P 0G5
      Phone #: 613-788-3311
      800 #: 800-685-8820
      e-mail: [email protected]
      Home page: http://www.cbcn.ca
    • Friends of Cancer Research
      2231 Crystal Drive
      Arlington VA 22202
      Phone #: 703-302-1503
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.focr.org
    • Lance Armstrong Foundation
      PO Box 161550
      Austin TX 78716-1150
      Phone #: 512-236-8820
      800 #: 866-235-7205
      e-mail: N/A
      Home page: http://www.livestrong.org
    • National Alliance of Breast Cancer Organizations
      9 East 37th Street
      New York NY 10016
      Phone #: 212-889-0606
      800 #: 888-806-2226
      e-mail: [email protected]
      Home page: http://www.nabco.org
    • National Breast Cancer Coalition
      1707 L Street Northwest
      Washington DC 20036
      Phone #: 202-296-7477
      800 #: 800-622-2838
      e-mail: [email protected]
      Home page: http://www.natlbcc.org
    • National Cancer Institute
      6116 Executive Blvd, MSC 8322, Room 3036A
      Bethesda MD 20892-8322
      Phone #: 301-435-3848
      800 #: 800-422-6237
      e-mail: N/A
      Home page: http://www.cancer.gov
    • National Cancer Institute Physician Data Query (PDQ) Cancer Information Service
      9000 Rockville Pike
      Bethesda MD 20892
      Phone #: --
      800 #: 800-422-6237
      e-mail: N/A
      Home page: http://www.cancernet.nci.nih.gov/pdq.html
    • National Women's Health Network
      514 10th Street NW
      Washington D.C. 20004
      Phone #: 202-628-7814
      800 #: --
      e-mail: [email protected]
      Home page: http://www.womenshealthnetwork.org
    • OncoLink: The University of Pennsylvania Cancer Center Resource
      3400 Spruce Street
      Philadelphia PA 19104-4283
      Phone #: 215-349-5445
      800 #: --
      e-mail: [email protected]
      Home page: http://www.oncolink.upenn.edu
    • SHARE - Self-Help For Women With Breast or Ovarian Cancer
      1501 Broadway
      New York NY 10036
      Phone #: 212-719-0364
      800 #: --
      e-mail: N/A
      Home page: http://www.sharecancersupport.org
    • Skin Cancer Foundation
      245 Fifth Avenue
      New York NY 10016
      Phone #: N/A
      800 #: 800-754-6490
      e-mail: [email protected]
      Home page: http://www.skincancer.org
    • Wellness Community
      919 18th Street N.W.
      Washington DC 20006
      Phone #: 202-659-9709
      800 #: 888-793-9355
      e-mail: [email protected]
      Home page: http://www.thewellnesscommunity.org
    • Y-ME National Breast Cancer Organization
      212 West Van Buren
      Chicago IL 60607-3908
      Phone #: 312-986-8338
      800 #: 800-986-8228
      e-mail: [email protected]
      Home page: http://www.y-me.org

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html