Diseases & Conditions


Porphyria, Variegate

Synonyms of Porphyria, Variegate
  • Mixed Hepatic Porphyria
  • Porphyria Cutanea Tarda Hereditaria
  • Porphyria Hepatica, Variegate
  • South African Genetic Porphyria
  • VP

Disorder Subdivisions

    General Discussion
    Variegate Porphyria (VP), a form of hepatic porphyria, is most common in the South African white population and is much less frequent elsewhere. It is an autosomal dominant disorder and may produce acute attacks (as in acute intermittent porphyria) as well as skin photosensitivity. This form of porphyria is also due to an enzyme deficiency.

    The diagnosis may be made by finding excess coproporphyrin in urine and both coproporphyrin and protoporphyrin in feces. In patients with photosensitive skin changes alone, it is important to distinguish Varigate Porphyria or hereditary coproporphyria (HCP) from porphyria cutanea tarda (PCT), because treatment by phlebotomy or low-dose chloroquine is not successful in VP and HCP. Acute attacks are managed and may be prevented as in AIP.

    The Porphyrias are a group of at least seven disorders. The common feature in all porphyrias is the excess accumulation in the body of porphyrins or porphyrin precursors. These are natural chemicals that normally do not accumulate in the body. Precisely which one of these porphyrin chemicals builds up depends upon the type of porphyria that a patient has.

    Porphyrias can also be classified into two groups: the hepatic and erythropoietic types. Porphyrins and related substances originate in excess amounts from the liver in the hepatic types, and mostly from the bone marrow in the erythropoietic types.

    The porphyrias with skin manifestations are sometimes called cutaneous porphyrias. The acute porphyrias are characterized by sudden attacks of pain and other neurological manifestations. These acute symptoms can be both rapidly-appearing and severe. An individual may be considered in a latent condition if he or she has the characteristic enzyme deficiency, but has never developed symptoms. There can be a wide spectrum of severity between the latent and active cases of any particular type of this disorder. The symptoms and treatments of the different types of porphyrias are not the same.

    Organizations related to Porphyria, Variegate
    • American Porphyria Foundation
      4900 Woodway
      Houston TX 77056
      Phone #: 713-266-9617
      800 #: --
      e-mail: [email protected]
      Home page: http://www.porphyriafoundation.com
    • CLIMB (Children Living with Inherited Metabolic Diseases)
      Climb Building
      Crewe Intl CW2 6BG
      Phone #: +44- 87-0 7700 325
      800 #: --
      e-mail: [email protected]
      Home page: http://www.CLIMB.org.uk
    • Canadian Association for Porphyria
      P.O. Box 1206
      Manitoba Intl ROJ 1HO
      Phone #: (20-4)4-76-2800
      800 #: N/A
      e-mail: N/A
      Home page: http://www.cpf-inc.ca/
    • Medic Alert Foundation International
      2323 Colorado Avenue
      Turlock CA 95382
      Phone #: 209-669-2401
      800 #: 800-432-5378
      e-mail: [email protected]
      Home page: http://www.medicalert.org
    • NIH/National Digestive Diseases Information Clearinghouse
      2 Information Way
      Bethesda MD 20892-3570
      Phone #: 301-654-3810
      800 #: 800-891-5389
      e-mail: [email protected]
      Home page: http://www.niddk.nih.gov

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html