Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Acquired Aplastic Anemia


Synonyms of Acquired Aplastic Anemia
  • Idiopathic Aplastic Anemia

Disorder Subdivisions



    General Discussion
    Acquired aplastic anemia is a rare disorder caused by profound, almost complete bone marrow failure. Bone marrow is the spongy substance found in the center of the long bones of the body. The bone marrow produces specialized cells (hematopoietic stem cells) that grow and eventually develop into red blood cells (erythrocytes), white blood cells (leukocytes), and platelets. In acquired aplastic anemia, an almost complete absence of hematopoietic stem cells eventually results in low levels of red and white blood cells and platelets (pancytopenia). Specific symptoms associated with acquired aplastic anemia may vary, but include fatigue, chronic infections, dizziness, weakness, headaches, and episodes of excessive bleeding. Although some cases of acquired aplastic anemia occur secondary to other disorders, researchers now believe that most cases result from a disorder of the patient?s immune system, in which the immune system mistakenly targets the bone marrow (autoimmunity). This is based on the response of approximately half of patients to immunotherapy, whether it is ATG, cyclosporine, high-dose steroids or cyclophosphamide.

    Organizations related to Acquired Aplastic Anemia
    • Anemia Institute for Research and Education
      151 Bloor Street West
      Toronto, Ontario None M5S 1S4
      Phone #: 416--96-9-7431
      800 #: 877--99-2-6364
      e-mail: info@anemiainstitute.org
      Home page: http://www.anemiainstitute.org
    • Aplastic Anemia & MDS International Foundation, Inc.
      P.O. Box 310
      Churchton MD 20733
      Phone #: 410-867-0242
      800 #: 800-747-2820
      e-mail: info@aamds.org
      Home page: http://www.aamds.org
    • Aplastic Anemia & Myelodysplasia Association of Canada
      11181 Yonge Street,Suite 321
      Ontario Intl L4S 1L2
      Phone #: 905-780-0698
      800 #: N/A
      e-mail: info@aamac.ca
      Home page: http://www.aamac.ca
    • Dubowitz Syndrome Support
      c/o 106 Verndale Street
      Warwick RI 02889-3242
      Phone #: 401-737-3138
      800 #: N/A
      e-mail: dubowitzsyndrome@netzero.net
      Home page: http://www.dubowitzsyndrome.net
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • NIH/Hematology Branch, National Heart, Lung and Blood Institute (NHLBI)
      10 Center Dr, Building 10-CRC
      Bethesda MD 20892-1202
      Phone #: 301-402-0764
      800 #: --
      e-mail: zamaniw@nhlbi.nih.gov
      Home page: http://dir.nhlbi.nih.gov/labs/hb/index.asp?
    • NIH/National Heart, Lung and Blood Institute
      31 Center Drive MSC 2480
      Bethesda MD 20892-2480
      Phone #: 301-592-8573
      800 #: --
      e-mail: nhlbiinfo@rover.nhlbi.nih.gov
      Home page: http://www.nhlbi.nih.gov/



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html