Diseases & Conditions


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Adams Oliver Syndrome


Synonyms of Adams Oliver Syndrome
  • Absence Defect of Limbs, Scalp and Skull
  • Aplasia Cutis Congenita with Terminal Transverse Limb Defects
  • Congenital Scalp Defects with Distal Limb Reduction Anomalies

Disorder Subdivisions



    General Discussion
    Adams-Oliver syndrome (AOS) is an extremely rare inherited disorder characterized by defects of the scalp and abnormalities of the fingers, toes, arms, and/or legs. The physical abnormalities associated with this disorder vary greatly among affected individuals. Some cases may be very mild while others may be severe. In infants with Adams-Oliver syndrome, scalp defects are present at birth (congenital) and may include one or multiple hairless scarred areas that may have abnormally wide (dilated) blood vessels directly under the affected skin. In severe cases, an underlying defect of the bones of the skull may also be present. In addition, infants with this disorder typically have malformations of the hands, arms, feet, and/or legs. These range from abnormally short (hypoplastic) fingers and toes to absent hands and/or lower legs. In some cases, additional abnormalities may also be present. Most cases of AOS appear to follow autosomal dominant inheritance but autosomal recessive inheritance has also been reported.

    Organizations related to Adams Oliver Syndrome
    • AOSupport
      None
      None None None
      Phone #: N/A
      800 #: N/A
      e-mail: N/A
      Home page: http://www.aosupport.org
    • Adams Oliver Syndrome Support Group
      14 College View
      Deeside Intl CH5 4BY
      Phone #: 012-44 -816209
      800 #: --
      e-mail: sandy.ivins@btinternet.com
      Home page: N/A
    • Birth Defect Research for Children
      930 Woodcock Rd
      Orlando FL 32803
      Phone #: 407-895-0802
      800 #: --
      e-mail: staff@birthdefects.org
      Home page: http://www.birthdefects.org
    • NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
      1 AMS Circle
      Bethesda MD 20892-3675
      Phone #: 301-495-4484
      800 #: 877-226-4267
      e-mail: NIAMSinfo@mail.nih.gov
      Home page: http://www.niams.nih.gov/Health_Info



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html