Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Anemia, Pernicious


Synonyms of Anemia, Pernicious
  • Addison-Biermer Anemia
  • Addisonian Pernicious Anemia
  • Addison's Anemia
  • Primary Anemia

Disorder Subdivisions

  • Adult Onset Pernicious Anemia
  • Congenital Pernicious Anemia due to Defect of Intrinsic Factor
  • Enterocyte Cobalamin Malabsorption
  • Enterocyte Intrinsic Factor Receptor, Defect of
  • Gastric Intrinsic Factor, Failure of Secretion
  • Juvenile Intestinal Malabsorption of Vit B12


General Discussion
Pernicious anemia is a rare blood disorder characterized by the inability of the body to properly utilize vitamin B12, which is essential for the development of red blood cells. Most cases result from the lack of the gastric protein known as intrinsic factor, without which vitamin B12 cannot be absorbed.

The symptoms of pernicious anemia may include weakness, fatigue, an upset stomach, an abnormally rapid heartbeat (tachycardia), and/or chest pains. Recurring episodes of anemia (megaloblastic) and an abnormal yellow coloration of the skin (jaundice) are also common. Pernicious anemia is thought to be an autoimmune disorder, and certain people may have a genetic predisposition to this disorder.

There is a rare congenital form of pernicious anemia in which babies are born lacking the ability to produce effective intrinsic factor. There is also a juvenile form of the disease, but pernicious anemia typically does not appear before the age of 30. The onset of the disease is slow and may span decades. When the disease goes undiagnosed and untreated for a long period of time, it may lead to neurological complications. Nerve cells and blood cells need vitamin B12 to function properly.

Organizations related to Anemia, Pernicious
  • American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Avenue
    Eastpointe MI 48021
    Phone #: 586-776-3900
    800 #: 800-598-4668
    e-mail: aarda@aarda.org
    Home page: http://www.aarda.org/
  • AutoImmunity Community
    None
    None None None
    Phone #: (91-9) -552-9057
    800 #: N/A
    e-mail: bandrews@autoimmunitycommunity.org
    Home page: http://autoimmunitycommunity.org
  • Autoimmune Information Network, Inc
    PO Box 4121
    Brick NJ 08723
    Phone #: 732-664-9259
    800 #: N/A
    e-mail: autoimmunehelp@aol.com
    Home page: http://www.aininc.org
  • European Society for Immunodeficiencies (ESID)
    c/o Dr. Esther de Vries
    Hertogenbosch None 5200 ME's
    Phone #: +31- 73--6992965
    800 #: N/A
    e-mail: info@esid.org
    Home page: http://www.esid.org
  • NIH/National Heart, Lung and Blood Institute
    31 Center Drive MSC 2480
    Bethesda MD 20892-2480
    Phone #: 301-592-8573
    800 #: --
    e-mail: nhlbiinfo@rover.nhlbi.nih.gov
    Home page: http://www.nhlbi.nih.gov/
  • The Arc (a national organization on mental retardation)
    1010 Wayne Ave
    Silver Spring MD 20910
    Phone #: 301-565-3842
    800 #: 800-433-5255
    e-mail: info@thearc.org
    Home page: http://www.thearc.org/



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

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