Diseases & Conditions


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Autoimmune Polyendocrine Syndrome Type II


Synonyms of Autoimmune Polyendocrine Syndrome Type II
  • Diabetes Mellitus, Addison's Disease, Myxedema
  • Multiple Endocrine Deficiency Syndrome, Type II
  • PGA II
  • Polyglandular Autoimmune Syndrome, Type II
  • Polyglandular Deficiency Syndrome, Type II
  • Schmidt Syndrome

Disorder Subdivisions



    General Discussion
    Autoimmune polyendocrine syndrome type II, also known as Schmidt syndrome, is a rare autoimmune disorder in which there is a steep drop in production of several essential hormones by the glands that secrete these hormones. When first described, this disorder was thought to involve only adrenal insufficiency (Addison?s disease) and thyroid insufficiency (Hashimoto?s thyroiditis). However, over time, as more patients were studied, the scope of the disorder was expanded to include disorders of other underperforming endocrine glands. These include the gonads, which secrete sex hormones; the pancreas which secretes insulin and is intimately tied up with diabetes mellitus; and sometimes the parathyroid glands. Failure of the endocrine glands to function is usually accompanied by signs of malnutrition because the ability of the intestinal tract to absorb nutrients is reduced dramatically. Since the combination of affected glands differs from patient to patient, the signs of this disorder are diverse.

    Most cases of this disorder are sporadic although some clinical researchers believe that there is a familial or hereditary trait associated with AIPS-II. If so, it may involve a complex interaction among many genes.

    Organizations related to Autoimmune Polyendocrine Syndrome Type II
    • American Autoimmune Related Diseases Association, Inc.
      22100 Gratiot Avenue
      Eastpointe MI 48021
      Phone #: 586-776-3900
      800 #: 800-598-4668
      e-mail: aarda@aarda.org
      Home page: http://www.aarda.org/
    • American Diabetes Association
      National Call Center
      Alexandria VA 22311
      Phone #: 703-549-1500
      800 #: 800-342-2383
      e-mail: askADA@diabetes.org
      Home page: http://www.diabetes.org
    • AutoImmunity Community
      None
      None None None
      Phone #: (91-9) -552-9057
      800 #: N/A
      e-mail: bandrews@autoimmunitycommunity.org
      Home page: http://autoimmunitycommunity.org
    • Celiac Sprue Association/USA, Inc.
      P.O. Box 31700
      Omaha NE 68131-0700
      Phone #: 402-558-0600
      800 #: 877-272-4272
      e-mail: celiacs@csaceliacs.org
      Home page: http://www.csaceliacs.org
    • Myasthenia Gravis Foundation of America
      1821 University Ave. W.
      St. Paul MN 55104
      Phone #: 651-917-6256
      800 #: 800-541-5454
      e-mail: mgfa@myasthenia.org
      Home page: http://www.myasthenia.org
    • NIH/National Digestive Diseases Information Clearinghouse
      2 Information Way
      Bethesda MD 20892-3570
      Phone #: 301-654-3810
      800 #: 800-891-5389
      e-mail: nddic@info.niddk.nih.gov
      Home page: http://www.niddk.nih.gov
    • National Adrenal Diseases Foundation
      505 Northern Boulevard
      Great Neck NY 11021
      Phone #: 516-487-4992
      800 #: --
      e-mail: NADFmail@aol.com
      Home page: http://www.medhelp.org/nadf



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html