Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Duane Syndrome


Synonyms of Duane Syndrome
  • DR Syndrome
  • Duane radial ray syndrome (DRRS)
  • Duane's Retraction Syndrome
  • Eye Retraction Syndrome
  • Retraction Syndrome
  • Stilling-Turk-Duane Syndrome

Disorder Subdivisions

  • Duane Syndrome Type 2A, 2B, 2C
  • Duane Syndrome Type 3A, 3B, 3C
  • Duane Syndrome Type IA, 1B, 1C


General Discussion
Duane syndrome (DS) is an eye movement disorder present at birth (congenital) characterized by horizontal eye movement limitation [a limited ability to move the eye inward toward the nose (adduction), outward toward the ear (abduction), or in both directions]. In addition, when the affected eye(s) moves inward toward the nose, the eyeball retracts (pulls in) and the eye opening (palpebral fissure) narrows. In some cases, when the eye attempts to look inward, it moves upward (upshoot) or downward (downshoot).

Duane syndrome falls under the larger heading of strabismus (misalignment of the eyes) under the subclassification of incomitant strabismus (misalignment of the eyes that varies with gaze directions) and subheading of what was previously termed extraocular fibrosis syndromes (conditions associated with fibrosis of the muscles that move the eyes), now termed Congenital Cranial Dysinnervation Disorders (CCDDs). The CCDDs are a group of congenital neuromuscular diseases resulting from developmental errors in innervation, the abnormalities involve one or more cranial nerves/nuclei with absence of normal innervation and/or secondary aberrant innervation. The group includes Duane syndrome, congenital fibrosis of the extraocular muscles (CFEOM), congenital ptosis, Marcus Gunn Jaw winking, M?bius syndrome, Crocodile tears, horizontal gaze palsy and congenital facial palsy, but this is not an exhaustive list.

Duane syndrome has been subdivided clinically into three types: Type 1, Type 2, and Type 3.

Organizations related to Duane Syndrome
  • Let Them Hear Foundation
    1900 University Ave #101
    East Palo Alto CA 94303
    Phone #: 650-462-3143
    800 #: 877-735-2929
    e-mail: info@letthemhear.org
    Home page: http://www.letthemhear.org
  • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: mums@netnet.net
    Home page: http://www.netnet.net/mums/
  • March of Dimes Birth Defects Foundation
    1275 Mamaroneck Avenue
    White Plains NY 10605
    Phone #: 914-428-7100
    800 #: 888-663-4637
    e-mail: Askus@marchofdimes.com
    Home page: http://www.marchofdimes.com
  • NIH/National Eye Institute
    Building 31 Rm 6A32
    Bethesda MD 20892-2510
    Phone #: 301-496-5248
    800 #: --
    e-mail: 2020@nei.nih.gov
    Home page: http://www.nei.nih.gov/
  • NIH/Office of Rare Diseases
    Steve Groft, Pharm.D.
    Bethesda MD 20892-
    Phone #: 301-402-4336
    800 #: --
    e-mail: hh70f@nih.gov
    Home page: http://www.rarediseases.info.nih.gov/ord/
  • Schepens Eye Research Institute
    20 Staniford Street
    Boston MA 02114-2500
    Phone #: 617-912-0100
    800 #: --
    e-mail: geninfo@vision.eri.harvard.edu
    Home page: http://www.theschepens.org/



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html