Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Factor XIII Deficiency


Synonyms of Factor XIII Deficiency
  • Fibrinase Deficiency
  • Fibrinoligase Deficiency
  • Fibrin Stabilizing Factor Deficiency
  • Laki-Lorand Factor Deficiency
  • Plasma Transglutaminase Deficiency

Disorder Subdivisions

  • Acquired Factor XIII Deficiency
  • Congenital Factor XIII Deficiency


General Discussion
Factor XIII Deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. Associated symptoms and findings occur as the result of a deficiency in the blood clotting factor F13A1 (Factor XIII). In affected individuals, the blood fails to clot appropriately, resulting in poor wound healing. Blood may seep into surrounding soft tissues, resulting in local pain and swelling. Internal bleeding may occur; approximately 25 percent of affected individuals experience bleeding in the brain (intracranial hemorrhage). Factor XIII Deficiency may be inherited as an autosomal dominant genetic trait. The disease may also be acquired in association with other disorders such as Sickle Cell Disease or Henoch-Schonlein Purpura.

Organizations related to Factor XIII Deficiency
  • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: mums@netnet.net
    Home page: http://www.netnet.net/mums/
  • Madisons Foundation
    PO Box 241956
    Los Angeles CA 90024
    Phone #: 310-264-0826
    800 #: N/A
    e-mail: getinfo@madisonsfoundation.org
    Home page: http://www.madisonsfoundation.org
  • NIH/National Heart, Lung and Blood Institute
    31 Center Drive MSC 2480
    Bethesda MD 20892-2480
    Phone #: 301-592-8573
    800 #: --
    e-mail: nhlbiinfo@rover.nhlbi.nih.gov
    Home page: http://www.nhlbi.nih.gov/
  • National Hemophilia Foundation
    116 West 32nd Street
    New York NY 10001
    Phone #: 212-328-3737
    800 #: 800-424-2634
    e-mail: gwidlundDhemophilia.org
    Home page: http://www.hemophilia.org
  • World Federation of Hemophilia
    1425 Rene Levesque Boulevard West
    Quebec Intl H3G 1T7
    Phone #: 514--87-5-7944
    800 #: --
    e-mail: wfh@wfh.org
    Home page: http://www.wfh.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html