Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Familial Cold Autoinflammatory Syndrome


Synonyms of Familial Cold Autoinflammatory Syndrome
  • Familial cold urticaria
  • FCAS

Disorder Subdivisions



    General Discussion
    Familial cold autoinflammatory syndrome (FCAS), also known as familial cold urticaria, is a rare, inherited inflammatory disorder characterized by intermittent episodes of rash, fever, joint pain and other signs/symptoms of systemic inflammation triggered by exposure to cold. Onset of FCAS occurs during infancy and early childhood and persists throughout the patient's life.

    FCAS is one of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. These syndromes are characterized by fever, rash, and joint pain.

    FCAS shares symptoms, and should not be confused, with acquired cold urticaria, a more common condition mediated by different mechanisms that usually develops later in life and is rarely inherited.

    Organizations related to Familial Cold Autoinflammatory Syndrome
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • NIH/Office of Rare Diseases
      Steve Groft, Pharm.D.
      Bethesda MD 20892-
      Phone #: 301-402-4336
      800 #: --
      e-mail: hh70f@nih.gov
      Home page: http://www.rarediseases.info.nih.gov/ord/
    • NOMID Alliance, Inc.
      P.O. Box 590354
      San Francisco CA 94159
      Phone #: 415-831-8782
      800 #: N/A
      e-mail: site_manager@nomidalliance.net
      Home page: http://www.nomidalliance.net



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html