Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Fibrodysplasia Ossificans Progressiva (FOP)


Synonyms of Fibrodysplasia Ossificans Progressiva (FOP)
  • FOP
  • Myositis Ossificans Progressiva

Disorder Subdivisions



    General Discussion
    Fibrodysplasia ossificans progressiva (FOP) is a very rare inherited connective tissue disorder characterized by the abnormal development of bone in areas of the body where bone is not normally present (heterotopic ossification), such as the ligaments, tendons, and muscles. Specifically, this disorder causes the body?s skeletal muscles and soft connective tissue to undergo a metamorphosis, essentially a transformation into bone, progressively locking joints in place and making movement difficult or impossible. FOP is characterized by malformation of the big toe that is present at birth (congenital). As the disease progresses, there may be other skeletal malformations and the abnormal development of bone may lead to stiffness in affected areas and limited movement in affected joints (e.g.,knees, wrists, shoulders, spine, and/or neck).

    Fibrodysplasia ossificans progressiva usually begins during early childhood and progresses throughout life. Most cases of FOP occur as the result of a sporadic new mutation. The genetic mutation that results in this disorder has been identified. FOP is caused by the mutation of a gene in the BMP pathway, which is associated with the formation of the skeleton in the embryo and the repair of the skeleton following birth.

    Organizations related to Fibrodysplasia Ossificans Progressiva (FOP)
    • Fundaci?n FOP
      Bonpland 1964- Dto 3 PA (1414) Ciudad Aut?noma
      Buenos Aires None None
      Phone #: 54--911--15-4145-5391
      800 #: N/A
      e-mail: info@fundacionfop.org.ar
      Home page: http://www.fundacionfop.org.ar
    • International Fibrodysplasia Ossificans Progressiva Association
      P.O. Box 196217
      Winter Springs FL 32719-6217
      Phone #: 407-365-4194
      800 #: --
      e-mail: together@ifopa.org
      Home page: http://www.ifopa.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • March of Dimes Birth Defects Foundation
      1275 Mamaroneck Avenue
      White Plains NY 10605
      Phone #: 914-428-7100
      800 #: 888-663-4637
      e-mail: Askus@marchofdimes.com
      Home page: http://www.marchofdimes.com
    • NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
      1 AMS Circle
      Bethesda MD 20892-3675
      Phone #: 301-495-4484
      800 #: 877-226-4267
      e-mail: NIAMSinfo@mail.nih.gov
      Home page: http://www.niams.nih.gov/Health_Info
    • UCSF Fibrodysplasia Ossificans Progressiva Clinic
      533 Parnassus Avenue
      San Francisco CA 94143
      Phone #: 415-476-7242
      800 #: 888-689-8273
      e-mail: referral.center@ucsfmedctr.org
      Home page: http://www.ucsfhealth.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html