Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Fibromatosis, Congenital Generalized


Synonyms of Fibromatosis, Congenital Generalized
  • CGF
  • Infantile Myofibromatosis (IM)

Disorder Subdivisions

  • Congenital Multiple Fibromatosis


General Discussion
Congenital generalized fibromatosis (CGF) is a pediatric condition that is often now referred to as infantile myofibromatosis (IM). It is characterized by the formation of single or multiple noncancerous (benign) tumors that appear to be derived from cells forming certain supporting and binding tissues of the body and involuntary (smooth) muscle. These firm, nodular, potentially locally invasive tumors may involve the skin and underlying (subcutaneous) tissues, muscle tissue, bones, and/or certain internal organs (viscera).

In many cases, the tumors are present at birth (congenital), develop within the first few weeks of life, or may initially become apparent before the age of two years. Following initial growth and multiplication (proliferation) of tumor cells, the tumors usually eventually recede and disappear on their own (spontaneously). Those with solitary or multiple lesions without visceral involvement typically have a benign disease course. However, in infants with severe or widespread involvement of vital internal organs (i.e., multicentric, visceral involvement), potentially life-threatening complications may occur.
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Organizations related to Fibromatosis, Congenital Generalized
  • American Cancer Society, Inc.
    1599 Clifton Road NE
    Atlanta GA 30329
    Phone #: 404-320-3333
    800 #: 800-227-2345
    e-mail: N/A
    Home page: http://www.cancer.org
  • Friends of Cancer Research
    2231 Crystal Drive
    Arlington VA 22202
    Phone #: 703-302-1503
    800 #: N/A
    e-mail: info@focr.org
    Home page: http://www.focr.org
  • March of Dimes Birth Defects Foundation
    1275 Mamaroneck Avenue
    White Plains NY 10605
    Phone #: 914-428-7100
    800 #: 888-663-4637
    e-mail: Askus@marchofdimes.com
    Home page: http://www.marchofdimes.com
  • National Cancer Institute
    6116 Executive Blvd, MSC 8322, Room 3036A
    Bethesda MD 20892-8322
    Phone #: 301-435-3848
    800 #: 800-422-6237
    e-mail: N/A
    Home page: http://www.cancer.gov
  • National Cancer Institute Physician Data Query (PDQ) Cancer Information Service
    9000 Rockville Pike
    Bethesda MD 20892
    Phone #: --
    800 #: 800-422-6237
    e-mail: N/A
    Home page: http://www.cancernet.nci.nih.gov/pdq.html
  • OncoLink: The University of Pennsylvania Cancer Center Resource
    3400 Spruce Street
    Philadelphia PA 19104-4283
    Phone #: 215-349-5445
    800 #: --
    e-mail: editors@oncolink.upenn.edu
    Home page: http://www.oncolink.upenn.edu



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html