Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Infantile Neuroaxonal Dystrophy


Synonyms of Infantile Neuroaxonal Dystrophy
  • INAD
  • Seitelberger Disease

Disorder Subdivisions

  • Prenatal or Connatal Neuroaxonal Dystrophy


General Discussion
Infantile neuroaxonal dystrophy (INAD) is an extremely rare, inherited degenerative disorder of the nervous system characterized by abnormalities of nerve endings (axon terminals) within the brain and spinal cord (central nervous system) and outside the central nervous system (peripheral nerves). In most cases, infants and children with INAD appear to develop normally until approximately 14 to 18 months of age, when they may begin to experience progressively increased difficulties in walking. In other cases, symptoms may begin at approximately six to eight months of age, at which time infants may experience delays or an arrest in the acquisition of skills requiring the coordination of mental and physical activities (delayed psychomotor development).
The symptoms and physical characteristics associated with infantile neuroaxonal dystrophy are the result of swelling and degeneration of nerve endings (dystrophic axonal swellings or spheroids) within and without areas of the brain and spinal cord (central nervous system). In most cases, INAD is inherited as an autosomal recessive genetic trait.

Organizations related to Infantile Neuroaxonal Dystrophy
  • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: mums@netnet.net
    Home page: http://www.netnet.net/mums/
  • March of Dimes Birth Defects Foundation
    1275 Mamaroneck Avenue
    White Plains NY 10605
    Phone #: 914-428-7100
    800 #: 888-663-4637
    e-mail: Askus@marchofdimes.com
    Home page: http://www.marchofdimes.com
  • NIH/National Eye Institute
    Building 31 Rm 6A32
    Bethesda MD 20892-2510
    Phone #: 301-496-5248
    800 #: --
    e-mail: 2020@nei.nih.gov
    Home page: http://www.nei.nih.gov/
  • National Institute of Neurological Disorders and Stroke (NINDS)
    31 Center Drive
    Bethesda MD 20892-2540
    Phone #: 301-496-5751
    800 #: 800-352-9424
    e-mail: braininfo@ninds.nih.gov
    Home page: http://www.ninds.nih.gov/
  • United Leukodystrophy Foundation
    2304 Highland Drive
    Sycamore IL 60178
    Phone #: 815-895-3211
    800 #: 800-728-5483
    e-mail: office@ulf.org
    Home page: http://www.ulf.org/



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html