Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Kleine-Levin Syndrome


Synonyms of Kleine-Levin Syndrome
  • Familial Hibernation Syndrome
  • Kleine-Levin Hibernation Syndrome
  • Periodic Somnolence and Morbid Hunger

Disorder Subdivisions



    General Discussion
    Kleine-Levin syndrome is a rare disorder characterized by the need for excessive amounts of sleep (hypersomnolence), (i.e., up to 20 hours a day); excessive food intake (compulsive hyperphagia); and behavioral changes such as an abnormally uninhibited sexual drive. The disorder primarily affects adolescent males. When awake, affected individuals may exhibit irritability, lack of energy (lethargy), and/or lack of emotions (apathy). They may also appear confused (disoriented) and experience hallucinations. Symptoms of Kleine-Levin syndrome are cyclical. An affected individual may go for weeks or months without experiencing symptoms. When present, symptoms may persist for days to weeks. In some cases, the symptoms associated with Kleine-Levin syndrome eventually disappear with advancing age. However, episodes may recur later during life.

    The exact cause of Kleine-Levin syndrome is not known. However, researchers believe that in some cases, hereditary factors may cause some individuals to have a genetic predisposition to developing the disorder. It is thought that symptoms of Kleine-Levin syndrome may be related to malfunction of the portion of the brain that helps to regulate functions such as sleep, appetite, and body temperature (hypothalamus). Some researchers speculate that Kleine-Levin syndrome may be an autoimmune disorder.

    Organizations related to Kleine-Levin Syndrome
    • American Sleep Disorders Association
      1610 14th Street NW
      Rochester MN 55901
      Phone #: 507-287-6006
      800 #: --
      e-mail: asda@millcomm.com
      Home page: N/A
    • Kleine-Levin Syndrome Foundation
      PO Box 5382
      San Jose CA 95150-5382
      Phone #: 408-265-1099
      800 #: N/A
      e-mail: facts@klsfoundation.org
      Home page: http://www.klsfoundation.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • NIH/National Institute of Mental Health
      6001 Executive Blvd
      Rockville MD 20892-9663
      Phone #: 301-443-4513
      800 #: --
      e-mail: nimhinfo@nih.gov
      Home page: http://www.nimh.nih.gov/
    • National Institute of Neurological Disorders and Stroke (NINDS)
      31 Center Drive
      Bethesda MD 20892-2540
      Phone #: 301-496-5751
      800 #: 800-352-9424
      e-mail: braininfo@ninds.nih.gov
      Home page: http://www.ninds.nih.gov/
    • National Mental Health Association
      2001 North Beauregard Street
      Alexandria VA 22311
      Phone #: 703-684-7722
      800 #: 800-969-6642
      e-mail: infoctr@nmha.org
      Home page: http://www.nmha.org
    • National Mental Health Consumers' Self-Help Clearinghouse
      1211 Chestnut Street
      Philadelphia PA 19107-6312
      Phone #: 215-751-1810
      800 #: 800-553-4539
      e-mail: info@mhselfhelp.org
      Home page: http://www.mhselfhelp.org
    • National Sleep Foundation
      1522 K Street
      Washington D.C. 20005
      Phone #: 202-347-3471
      800 #: --
      e-mail: nsf@sleepfoundation.org
      Home page: http://www.sleepfoundation.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html