Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Muckle-Wells Syndrome


Synonyms of Muckle-Wells Syndrome
  • MWS

Disorder Subdivisions



    General Discussion
    Muckle-Wells syndrome (MWS) is one of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. These syndromes are characterized by fever, rash and joint pain.

    Individuals with MWS often have episodic fever, chills, and painful joints. Sometimes these symptoms are exacerbated by cold similar to the related condition FCAS, but can also be triggered by other stimuli. In most cases, Muckle-Wells syndrome (MWS) patients develop progressive hearing loss. In some MWS cases amyloidosis develops later in life, a disease in which an abnormal accumulation of the protein amyloid occurs in a patient's tissues and organs. Accumulation of amyloid in the kidneys results in damage and often kidney failure if untreated.

    Organizations related to Muckle-Wells Syndrome
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • NIH/Office of Rare Diseases
      Steve Groft, Pharm.D.
      Bethesda MD 20892-
      Phone #: 301-402-4336
      800 #: --
      e-mail: hh70f@nih.gov
      Home page: http://www.rarediseases.info.nih.gov/ord/
    • NOMID Alliance, Inc.
      P.O. Box 590354
      San Francisco CA 94159
      Phone #: 415-831-8782
      800 #: N/A
      e-mail: site_manager@nomidalliance.net
      Home page: http://www.nomidalliance.net



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html