Diseases & Conditions


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MURCS Association


Synonyms of MURCS Association
  • Mullerian Duct and Renal Agenesis with Upper Limb and Rib Anomalies
  • Mullerian Duct Aplasia-Renal Aplasia-Cervicothoracic Somite Dysplasia
  • Mullerian Duct-Renal-Cervicothoracic-Upper Limb Defects
  • Mullerian-Renal-Cervicothoracic Somite Abnormalities

Disorder Subdivisions



    General Discussion
    MURCS association is a very rare developmental disorder that affects only females. The acronym MURCS stands for (MU)llerian, (R)enal, (C)ervicothoracic (S)omite abnormalities. This rare disorder is characterized by the absence of the uterus, cervix, and upper part of the vagina (mullerian aplasia); kidney (renal) abnormalities, including absent (agenic) and/or improperly positioned (ectopic) kidneys; and/or malformations of the spinal column, ribs, and/or arms. Some affected females may exhibit additional physical abnormalities, such as malformations of the head and facial (craniofacial) area. In individuals with MURCS association, symptoms vary from case to case.

    MURCS association appears to occur randomly, with no apparent cause (sporadic). Some researchers suggest that the malformations associated with this disorder may result from abnormal changes in cellular material (blastema) in portions of the embryo that later develop into the arms, certain bones (vertebrae) in the spinal column, the kidneys, and adjacent structures (e.g., fallopian tubes).
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    Organizations related to MURCS Association
    • NIH/National Kidney and Urologic Diseases Information Clearinghouse
      3 Information Way
      Bethesda MD 20892-3580
      Phone #: N/A
      800 #: 800-891-5390
      e-mail: nkudic@info.niddk.nih.gov
      Home page: http://kidney.niddk.nih.gov/
    • National Kidney Foundation
      30 East 33rd Street
      New York NY 10016
      Phone #: 212-889-2210
      800 #: 800-622-9010
      e-mail: info@kidney.org
      Home page: http://www.kidney.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html