Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Neuroleptic Malignant Syndrome


Synonyms of Neuroleptic Malignant Syndrome
  • Drug-Induced Movement Disorder
  • Hyperthermia
  • Neuroleptic-Induced Acute Dystonia

Disorder Subdivisions



    General Discussion
    Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Several of the more commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine.

    The syndrome is characterized by high fever, stiffness of the muscles, altered mental status (paranoid behavior), and autonomic dysfunction. Autonomic dysfunction alludes to defective operations of the components of the involuntary (autonomic) nervous system, leading to wide swings of blood pressure, excessive sweating and excessive secretion of saliva.

    A genetic basis for the disorder is suspected but not proven. It does appear to be clear that a defect in the receptors to dopamine (dopamine D2 receptor antagonism) is an important contributor to the cause of neuroleptic malignant syndrome.

    Organizations related to Neuroleptic Malignant Syndrome
    • Malignant Hyperthermia Association of the United States (MHAUS)
      11 East State Street
      Sherburne NY 13460-1069
      Phone #: 607-674-7901
      800 #: --
      e-mail: info@mhaus.org
      Home page: http://www.mhaus.org
    • Medic Alert Foundation International
      2323 Colorado Avenue
      Turlock CA 95382
      Phone #: 209-669-2401
      800 #: 800-432-5378
      e-mail: Inquiries@medicalert.org
      Home page: http://www.medicalert.org
    • NIH/National Institute of Mental Health
      6001 Executive Blvd
      Rockville MD 20892-9663
      Phone #: 301-443-4513
      800 #: --
      e-mail: nimhinfo@nih.gov
      Home page: http://www.nimh.nih.gov/
    • National Alliance for the Mentally Ill
      Colonial Place Three
      Arlington VA 22201-3042
      Phone #: 703-524-7600
      800 #: 800-999-6264
      e-mail: membership@nami.org
      Home page: http://www.nami.org
    • National Mental Health Association
      2001 North Beauregard Street
      Alexandria VA 22311
      Phone #: 703-684-7722
      800 #: 800-969-6642
      e-mail: infoctr@nmha.org
      Home page: http://www.nmha.org
    • National Mental Health Consumers' Self-Help Clearinghouse
      1211 Chestnut Street
      Philadelphia PA 19107-6312
      Phone #: 215-751-1810
      800 #: 800-553-4539
      e-mail: info@mhselfhelp.org
      Home page: http://www.mhselfhelp.org
    • North American Malignant Hyperthermia Registry of MHAUS
      Children's Hospital of Pittsburgh
      Pittsburgh PA 15213-2583
      Phone #: 412-692-6390
      800 #: 888-274-7899
      e-mail: bwb+@pitt.edu
      Home page: http://www.mhreg.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html