Diseases & Conditions


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Neuropathy, Hereditary Sensory, Type II


Synonyms of Neuropathy, Hereditary Sensory, Type II
  • Acroosteolysis, Giaccai Type
  • Acroosteolysis, Neurogenic
  • Congenital Sensory Neuropathy
  • Hereditary Sensory and Autonomic Neuropathy, Type II (HSAN Type II)
  • Hereditary Sensory Radicular Neuropathy, Autosomal Recessive
  • HSAN II
  • Morvan Disease
  • Neuropathy, Progressive Sensory, of Children
  • Radicular Neuropathy, Sensory, Recessive
  • Sensory Radicular Neuropathy, Recessive

Disorder Subdivisions



    General Discussion
    The hereditary sensory neuropathies (HSN) include 4-6 similar but distinct inherited degenerative disorders of the nervous system (neurodegenerative) that frequently progress to loss of feeling, especially in the hands and feet. Some types of HSN are related to or identical with some forms of Charcot-Marie-Tooth disorder, and others are related to or identical with familial dysautonomia (Riley-Day syndrome). The classification of the HSNs is complicated, and the experts do not always agree on it.

    Hereditary sensory neuropathy type II (HSN2) is a rare genetic disorder that usually begins in childhood by affecting the nerves that serve the lower arms and hands and the lower legs and feet (the peripheral nerves). Symptoms start with inflamed fingers or toes especially around the nails. Infection is common and worsens as ulcers (open sores) form on the fingers and on the soles of the feet. The loss of sensation in both hands and feet often leads to neglect of the wounds. This can become serious, even leading to amputation in extreme cases, so it is important to care for any such wounds.

    The disorder affects many of the body?s systems, is characterized by early onset (infancy or early childhood) and is transmitted genetically as an autosomal recessive trait.

    Organizations related to Neuropathy, Hereditary Sensory, Type II
    • Jack Miller Center for Peripheral Neuropathy
      University of Chicago
      Chicago IL 60637
      Phone #: 773-702-5800
      800 #: N/A
      e-mail: information-millercenter@neurology.bsd.uchicago.edu
      Home page: http://millercenter.uchicago.edu
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • March of Dimes Birth Defects Foundation
      1275 Mamaroneck Avenue
      White Plains NY 10605
      Phone #: 914-428-7100
      800 #: 888-663-4637
      e-mail: Askus@marchofdimes.com
      Home page: http://www.marchofdimes.com
    • National Institute of Neurological Disorders and Stroke (NINDS)
      31 Center Drive
      Bethesda MD 20892-2540
      Phone #: 301-496-5751
      800 #: 800-352-9424
      e-mail: braininfo@ninds.nih.gov
      Home page: http://www.ninds.nih.gov/



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html