Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Nezelof Syndrome


Synonyms of Nezelof Syndrome
  • Alymphocytosis, Pure
  • Combined Immunodeficiency with Immunoglobulins
  • Immune Defect due to Absence of Thymus
  • Immunodeficiency Cellular, with Abnormal Immunoglobulin Synthesis
  • Severe Combined Immunodeficiency, Nezelof Type
  • Thymic Aplasia, Nezelof's
  • Thymic Dysplasia with Normal Immunoglobulins
  • T-Lymphocyte Deficiency

Disorder Subdivisions



    General Discussion
    Nezelof syndrome (NS) is an extremely rare immune deficiency disorder in which the cells that normally fight off even common infections do not function properly. Affected individuals are subject to frequent and serious infections. Because neither of the two main infection-fighting cells, T cells and B cells, functions properly, Nezelof syndrome is often referred to as a combined immunodeficiency disorder (CID). Patients with this syndrome usually have small thymus glands in which the cells producing hormones required for development of infection-fighting cells are flawed or malfunctioning.

    Nezelof syndrome is usually classified as a T cell deficiency, yet those affected do not have abnormal levels of gammaglobulin, a protein in blood that contains disease-fighting antibodies. T cell dysfunction in the presence of relatively normal concentrations of gammaglobulin is one way of defining Nezelof syndrome. Because there is some immunoglobulin function, NS is never as debilitating as severe combined immunodeficiency (SCID).

    Nezelof syndrome is an inherited condition that becomes apparent early in the life of the baby.

    Organizations related to Nezelof Syndrome
    • American Academy of Allergy, Asthma and Immunology
      611 East Wells Street
      Milwaukee WI 53202
      Phone #: 414-272-6071
      800 #: 800-822-2762
      e-mail: info@aaaai.org
      Home page: http://www.aaaai.org
    • European Society for Immunodeficiencies (ESID)
      c/o Dr. Esther de Vries
      Hertogenbosch None 5200 ME's
      Phone #: +31- 73--6992965
      800 #: N/A
      e-mail: info@esid.org
      Home page: http://www.esid.org
    • Immune Deficiency Foundation
      40 West Chesapeake Avenue
      Towson MD 21204
      Phone #: 410-321-6647
      800 #: 800-296-4433
      e-mail: idf@primaryimmune.org
      Home page: http://www.primaryimmune.org
    • International Patient Organization for Primary Immunodeficiencies
      Firside
      Cornwall None PL11 3LE
      Phone #: 44 -150-3 250 668
      800 #: --
      e-mail: info@ipopi.org
      Home page: http://www.ipopi.org/
    • Jeffrey Modell Foundation
      747 Third Ave
      New York NY 10017
      Phone #: 212-819-0200
      800 #: 866-469-6474
      e-mail: info@jmfworld.org
      Home page: http://www.info4pi.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: mums@netnet.net
      Home page: http://www.netnet.net/mums/
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: getinfo@madisonsfoundation.org
      Home page: http://www.madisonsfoundation.org
    • March of Dimes Birth Defects Foundation
      1275 Mamaroneck Avenue
      White Plains NY 10605
      Phone #: 914-428-7100
      800 #: 888-663-4637
      e-mail: Askus@marchofdimes.com
      Home page: http://www.marchofdimes.com
    • NIH/National Institute of Allergy and Infectious Diseases
      6610 Rockledge Drive
      Bethesda MD 20892-6612
      Phone #: 301-496-5717
      800 #: --
      e-mail: N/A
      Home page: http://www.niaid.nih.gov/



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html