Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Polycystic Kidney Disease, Autosomal Dominant


Synonyms of Polycystic Kidney Disease, Autosomal Dominant
  • ADPKD

Disorder Subdivisions



    General Discussion
    Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the formation of cysts within the kidneys. Symptoms caused by cyst formation in the kidneys include high blood pressure (hypertension), pain on the sides of the body between the last rib and the hip (flank pain), blood in the urine (hematuria) and progressively poor function of the kidneys (kidney insufficiency). In approximately 50 percent of cases, ADPKD eventually progresses to cause end stage renal disease, requiring renal replacement therapy, either dialysis or renal transplantation. ADPKD is not simply a kidney disorder and other organ systems of the body can potentially be affected (multisystem disorder) by the development of cysts. The specific symptoms present in each person depend upon the specific organ systems involved. The liver, pancreas, a membrane covering the spinal cord and brain (arachnoid membrane), the prostate, and the glands of the male reproductive tract that produce fluid that is part of semen (seminal vesicles) may become involved. Abnormalities affecting the heart and blood vessels (cardiovascular system) may also occur in individuals with ADPKD. ADPKD usually does not become apparent until the fourth or fifth decade and was once known as ?adult? polycystic kidney disease. However, it has been reported in children and infants. ADPKD is caused by mutations of one of two genes that create certain proteins essential for the proper health of the kidneys and other parts of the body.

    Organizations related to Polycystic Kidney Disease, Autosomal Dominant
    • American Association of Kidney Patients
      3505 East Frontage Road
      Tampa FL 33607
      Phone #: 813-636-8100
      800 #: 800-749-2257
      e-mail: info@aakp.org
      Home page: http://www.aakp.org
    • American Kidney Fund, Inc.
      6110 Executive Boulevard
      Rockville MD 20852
      Phone #: 301-881-3052
      800 #: 800-638-8299
      e-mail: helpline@kideyfund.org
      Home page: http://www.kidneyfund.org
    • NIH/National Kidney and Urologic Diseases Information Clearinghouse
      3 Information Way
      Bethesda MD 20892-3580
      Phone #: N/A
      800 #: 800-891-5390
      e-mail: nkudic@info.niddk.nih.gov
      Home page: http://kidney.niddk.nih.gov/
    • National Hypertension Association, Inc.
      324 East 30th Street
      New York NY 10016
      Phone #: 212-889-3557
      800 #: 800-575-9355
      e-mail: nathypertension@aol.com
      Home page: http://www.nathypertension.org
    • National Kidney Foundation
      30 East 33rd Street
      New York NY 10016
      Phone #: 212-889-2210
      800 #: 800-622-9010
      e-mail: info@kidney.org
      Home page: http://www.kidney.org
    • PKD Foundation
      9221 Ward Parkway
      Kansas City MO 64114-3367
      Phone #: 816-931-2600
      800 #: 800-753-2873
      e-mail: pkdcure@pkdcure.org
      Home page: http://www.pkdcure.org



    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html