Diseases & Conditions


A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Tricho Dento Osseous Syndrome


Synonyms of Tricho Dento Osseous Syndrome
  • TDO Syndrome

Disorder Subdivisions

  • TDO-I
  • TDO-II
  • TDO-III


General Discussion
Tricho-dento-osseous (TDO) syndrome is an autosomal dominant genetic disorder that belongs to a group of diseases known as ectodermal dysplasias. Ectodermal dysplasias typically affect the hair, teeth, nails, and/or skin. TDO syndrome is characterized by kinky or curly hair; poorly developed tooth enamel; and unusual thickness and/or denseness (sclerosis) of the top portion of the skull (calvaria) and/or the long bones (i.e., bones in the arms and legs). In some cases, affected individuals also exhibit abnormally thin, brittle nails or premature closure (fusion) of the fibrous joints between certain bones in the skull (craniosynostosis), causing the head to appear abnormally long and narrow (dolicocephaly).

There may be three distinct types of TDO syndrome. Some researchers suggest that these variants may be differentiated mainly by whether the calvaria and/or long bones exhibit abnormal hardening (sclerosis), thickening, and/or density. Other symptoms also vary among the three disorder types.

Organizations related to Tricho Dento Osseous Syndrome
  • AmeriFace
    PO Box 751112
    Las Vegas NV 89136
    Phone #: 702-769-9264
    800 #: 888-486-1209
    e-mail: info@ameriface.org
    Home page: http://www.ameriface.org
  • Children's Craniofacial Association
    13140 Coit Road
    Dallas TX 75240
    Phone #: 214-570-9099
    800 #: 800-535-3643
    e-mail: csmith@ccakids.com
    Home page: http://www.ccakids.com
  • Craniofacial Foundation of America
    975 East Third Street
    Chattanooga TN 37403
    Phone #: 423-778-9192
    800 #: 800-418-3223
    e-mail: farmertm@erlanger.org
    Home page: http://www.craniofacialcenter.com
  • FACES: The National Craniofacial Association
    P.O. Box 11082
    Chattanooga TN 37401
    Phone #: 423-266-1632
    800 #: 800-332-2373
    e-mail: faces@faces-cranio.org
    Home page: http://www.faces-cranio.org
  • NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
    1 AMS Circle
    Bethesda MD 20892-3675
    Phone #: 301-495-4484
    800 #: 877-226-4267
    e-mail: NIAMSinfo@mail.nih.gov
    Home page: http://www.niams.nih.gov/Health_Info
  • NIH/National Oral Health Information Clearinghouse
    1 NOHIC Way
    Bethesda MD 20892-3500
    Phone #: 301-402-7364
    800 #: --
    e-mail: nohic@nidcr.nih.gov
    Home page: http://www.nohic.nidcr.nih.gov
  • National Craniofacial Foundation
    3100 Carlisle Street
    Dallas TX 75204
    Phone #: --
    800 #: 800-535-3643
    e-mail: N/A
    Home page: N/A
  • National Foundation for Ectodermal Dysplasias
    410 East Main Street
    Mascoutah IL 62258-0114
    Phone #: 618-566-2020
    800 #: --
    e-mail: info@nfed.org
    Home page: http://www.nfed.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html