WAGR Syndrome / Disease

Diseases & Conditions

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WAGR Syndrome

Synonyms of WAGR Syndrome

11p deletion syndrome
Chromosome 11p deletion syndrome
WAGR Complex
Wilms' Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome
Wilms' Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Disorder Subdivisions

AGR Triad
Aniridia-Ambiguous Genitalia-Mental Retardation
Aniridia-Wilms' Tumor Association
Aniridia-Wilms' Tumor-Gonadoblastoma
AWTA

General Discussion
WAGR syndrome is a rare genetic syndrome in which there is a predisposition to several conditions, including certain malignancies, distinctive eye abnormalities, and/or mental retardation. WAGR is an acronym for the characteristic abnormalities associated with the syndrome. The acronym stands for (W)ilms' Tumor, the most common form of kidney cancer in children; (A)niridia, partial or complete absence of the colored region of the eye(s) (iris or irides); (G) Genitourinary abnormalities, such as undescended testicles or hypospadias in males, or internal genital or urinary anomalies in females; and Mental (R)etardation. A combination of two or more of these conditions is usually present in most individuals with WAGR syndrome. The clinical picture varies, depending upon the combination of associated abnormalities.

WAGR syndrome is caused by defects (mutations) of adjacent genes on a region of chromosome 11 (11p13). In most cases, such genetic changes (e.g., deletions at band 11p13) occur spontaneously during early embryonic development (de novo) for unknown reasons (sporadic). In very rare cases, the mutation may be inherited as the result of a rearrangement of parts of two chromosomes, which causes the loss of some genetic material (translocation) or other heritable genetic abnormality. The presence of more than one type of chromosomal makeup within an individual (mosaic deletion) resulting in WAGR syndrome has also been reported.

Organizations related to WAGR Syndrome

Ambiguous Genitalia Support Network
P.O. Box 313
Clements CA 95227-0313
Phone #: N/A
800 #: --
e-mail: agsn@inreach.com
Home page: N/A
American Cancer Society, Inc.
1599 Clifton Road NE
Atlanta GA 30329
Phone #: 404-320-3333
800 #: 800-227-2345
e-mail: N/A
Home page: http://www.cancer.org
American Kidney Fund, Inc.
6110 Executive Boulevard
Rockville MD 20852
Phone #: 301-881-3052
800 #: 800-638-8299
e-mail: helpline@kideyfund.org
Home page: http://www.kidneyfund.org
Aniridia Network
17 Sandmartin Crescent
Colchester, Essex None CO3 8WQ
Phone #: 44 -077-79 859 624
800 #: N/A
e-mail: Hannah@aniriddia.org
Home page: http://www.aniridia.org
Candlelighters Childhood Cancer Foundation
P.O. Box 498
Kensington MD 20895-0498
Phone #: 301-962-3520
800 #: 800-366-2223
e-mail: staff@candlelighters,org
Home page: http://www.candlelighters.org
Friends of Cancer Research
2231 Crystal Drive
Arlington VA 22202
Phone #: 703-302-1503
800 #: N/A
e-mail: info@focr.org
Home page: http://www.focr.org
Glaucoma Research Foundation
490 Post Street
San Francisco CA 94102
Phone #: 415-986-3162
800 #: 800-826-6693
e-mail: info@glaucoma.org
Home page: http://www.glaucoma.org
International WAGR Syndrome Association
PO Box 392
Allen Park MI 48101
Phone #: N/A
800 #: --
e-mail: ReachingOut@wagr.org
Home page: http://www.wagr.org
MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay WI 54301-1243
Phone #: 920-336-5333
800 #: 877-336-5333
e-mail: mums@netnet.net
Home page: http://www.netnet.net/mums/
Madisons Foundation
PO Box 241956
Los Angeles CA 90024
Phone #: 310-264-0826
800 #: N/A
e-mail: getinfo@madisonsfoundation.org
Home page: http://www.madisonsfoundation.org
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains NY 10605
Phone #: 914-428-7100
800 #: 888-663-4637
e-mail: Askus@marchofdimes.com
Home page: http://www.marchofdimes.com
NIH/National Eye Institute
Building 31 Rm 6A32
Bethesda MD 20892-2510
Phone #: 301-496-5248
800 #: --
e-mail: 2020@nei.nih.gov
Home page: http://www.nei.nih.gov/
National Eye Research Foundation
910 Skokie Boulevard
Northbrook IL 60062
Phone #: 847-564-4652
800 #: 800-621-2258
e-mail: nerf1955@aol.com
Home page: http://www.nerf.org
National Kidney Foundation
30 East 33rd Street
New York NY 10016
Phone #: 212-889-2210
800 #: 800-622-9010
e-mail: info@kidney.org
Home page: http://www.kidney.org
Wellness Community
919 18th Street N.W.
Washington DC 20006
Phone #: 202-659-9709
800 #: 888-793-9355
e-mail: help@thewellnesscommunity.org
Home page: http://www.thewellnesscommunity.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html