Diseases & Conditions


Antiphospholipid Syndrome

Synonyms of Antiphospholipid Syndrome
  • Antiphospholipid Antibody Syndrome
  • APLS
  • APS
  • Hughes Syndrome
  • Lupus Anticoagulant Syndrome
  • PAPS
  • Primary Antiphospholipid Syndrome

Disorder Subdivisions

  • CAPS
  • Catastrophic Antiphospholipid Syndrome (Asherson?s Syndrome)

General Discussion
Antiphospholipid syndrome (APS) is a rare immunological disorder characterized by recurring blood clots. Blood clots can form in any blood vessel of the body. The specific symptoms and severity of APS vary greatly from case to case depending upon the exact location of a blood clot and the organ system affected. APS may occur as an isolated disorder (primary antiphospholipid syndrome) or may occur along with another autoimmune disorder such as systemic lupus erythematosus (secondary antiphospholipid syndrome).

APS is characterized by the presence of antiphospholipid antibodies in the body. Antibodies are specialized proteins produced by the body?s immune system to fight infections. In individuals with APS, certain antibodies mistakenly attack healthy tissue. This healthy tissue is a certain proteins that bind to phospholipids. Phospholipids are a type of fat molecule that is involved in the proper function of cell membranes and found throughout the body. The reason for these antiphospholipid antibodies attacking the phospholipid proteins and the process by which they cause blood clots is not known.

Organizations related to Antiphospholipid Syndrome
  • APS Foundation of America, Inc
    PO Box 801
    La Crosse WI 54602-0801
    Phone #: 608-782-2626
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.apsfa.org
  • American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Avenue
    Eastpointe MI 48021
    Phone #: 586-776-3900
    800 #: 800-598-4668
    e-mail: [email protected]
    Home page: http://www.aarda.org/
  • Antiphospholipid Antibody Support Group
    Marvin Nelson
    Apex NC 27539-7282
    Phone #: 919-362-8977
    800 #: N/A
    e-mail: N/A
    Home page: http://www.egroups.com/group/aplsuk
  • AutoImmunity Community
    None None None
    Phone #: (91-9) -552-9057
    800 #: N/A
    e-mail: [email protected]
    Home page: http://autoimmunitycommunity.org
  • Autoimmune Information Network, Inc
    PO Box 4121
    Brick NJ 08723
    Phone #: 732-664-9259
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.aininc.org
  • European Society for Immunodeficiencies (ESID)
    c/o Dr. Esther de Vries
    Hertogenbosch None 5200 ME's
    Phone #: +31- 73--6992965
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.esid.org
  • Hughes Syndrome Foundation
    Louise Coote Lupus Unit
    London None SE1 7EH
    Phone #: 020-7-1-88-8217
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.hughes-syndrome.org
  • International Scleroderma Network
    7455 France Ave So #266
    Edina MN 55435
    Phone #: 952-831-3091
    800 #: 800-564-7099
    e-mail: [email protected]
    Home page: http://www.sclero.org
  • Lupus Foundation of America, Inc.
    2000 L Street NW
    Washington DC 20036
    Phone #: 202-349-1155
    800 #: 800-558-0121
    e-mail: [email protected]
    Home page: http://www.lupus.org
  • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: [email protected]
    Home page: http://www.netnet.net/mums/
  • Madisons Foundation
    PO Box 241956
    Los Angeles CA 90024
    Phone #: 310-264-0826
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.madisonsfoundation.org
  • National Alliance for Thrombosis and Thrombophilia
    120 White Plains Road
    Tarrytown NY 10591
    Phone #: 914-220-5040
    800 #: 877-466-2568
    e-mail: [email protected]
    Home page: http://stoptheclot.org/index.htm
  • National Stroke Association
    9707 East Easter Lane
    Englewood CO 80112-3747
    Phone #: 303-649-9299
    800 #: 800-787-6537
    e-mail: [email protected]
    Home page: http://www.stroke.org
  • Platelet Disorder Support Association
    133 Rollins Avenue
    Rockville MD 20852
    Phone #: 301-770-6636
    800 #: 877-528-3538
    e-mail: [email protected]
    Home page: http://www.pdsa.org
  • Thrombophilia Awareness Project
    None None None
    Phone #: --
    800 #: --
    e-mail: [email protected]
    Home page: http://www.fvleiden.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html