Diseases & Conditions


Asherson's Syndrome

Synonyms of Asherson's Syndrome
  • CAPS
  • Catastrophic Antiphospholipid Syndrome

Disorder Subdivisions

    General Discussion
    Asherson?s syndrome is an extremely rare autoimmune disorder characterized by the development, over a period of hours, days or weeks, of rapidly progressive blood clots affecting multiple organ systems of the body. Conditions such as infections, immunizations, wounds caused due to physical trauma and failure in the anticoagulation mechanism of the body usually act as triggers.

    The syndrome is particularly common among patients with antiphospholipid syndrome who experience a cessation of the anticoagulation mechanism rleated to recurrent bleeding in the body. It is usually seen in patients who have previously suffered from a simple/classic episode of antiphospholipid syndrome. It is not known why patients of antiphospholipid syndrome often have the tendency to be catapulted into a serious or fatal multiorgan failure, while the same triggers in other individuals may only result in recurrent large vessel thrombosis. The symptoms are also aptly observed in patients during pregnancy or in the weeks after childbirth (puerperium) and may follow the HELLP syndrome or be associated with malignancies. Symptoms vary from case to case depending upon the specific organ systems involved. Asherson?s syndrome can rapidly result in life-threatening multiorgan failure.

    Asherson?s syndrome is a severe variant of antiphospholipid syndrome (APS), an autoimmune disorder in which blood clots occur in relation to the presence of antiphospholipid antibodies in the body. Antibodies are specialized proteins produced by the body?s immune system to fight infection. In autoimmune disorders, antibodies mistakenly attack healthy tissue. In APS and Asherson?s syndrome, antibodies mistakenly attack certain proteins that bind to phospholipids, which are fat molecules that are involved in the proper function of cell membranes. Phospholipids are found throughout the body. The reason these antibodies attack these proteins and the process by which they cause blood clots to form is not known.

    Asherson?s syndrome may occur in individuals who have primary or secondary APS or in individuals with lupus or other autoimmune disorders. In some cases, no previous history of these disorders may be present. The exact cause of Asherson?s syndrome is unknown.

    Organizations related to Asherson's Syndrome
    • APS Foundation of America, Inc
      PO Box 801
      La Crosse WI 54602-0801
      Phone #: 608-782-2626
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.apsfa.org
    • American Autoimmune Related Diseases Association, Inc.
      22100 Gratiot Avenue
      Eastpointe MI 48021
      Phone #: 586-776-3900
      800 #: 800-598-4668
      e-mail: [email protected]
      Home page: http://www.aarda.org/
    • Antiphospholipid Antibody Support Group
      Marvin Nelson
      Apex NC 27539-7282
      Phone #: 919-362-8977
      800 #: N/A
      e-mail: N/A
      Home page: http://www.egroups.com/group/aplsuk
    • AutoImmunity Community
      None None None
      Phone #: (91-9) -552-9057
      800 #: N/A
      e-mail: [email protected]
      Home page: http://autoimmunitycommunity.org
    • Autoimmune Information Network, Inc
      PO Box 4121
      Brick NJ 08723
      Phone #: 732-664-9259
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.aininc.org
    • Lupus Foundation of America, Inc.
      2000 L Street NW
      Washington DC 20036
      Phone #: 202-349-1155
      800 #: 800-558-0121
      e-mail: [email protected]
      Home page: http://www.lupus.org
    • National Alliance for Thrombosis and Thrombophilia
      120 White Plains Road
      Tarrytown NY 10591
      Phone #: 914-220-5040
      800 #: 877-466-2568
      e-mail: [email protected]
      Home page: http://stoptheclot.org/index.htm
    • National Stroke Association
      9707 East Easter Lane
      Englewood CO 80112-3747
      Phone #: 303-649-9299
      800 #: 800-787-6537
      e-mail: [email protected]
      Home page: http://www.stroke.org

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html