Diseases & Conditions


Idiopathic Thrombocytopenic Purpura

Synonyms of Idiopathic Thrombocytopenic Purpura
  • ITP
  • Purpura Hemorrhagica ITP
  • Werlhof disease

Disorder Subdivisions

    General Discussion
    Idiopathic thrombocytopenic purpura (ITP) is a rare autoimmune bleeding disorder characterized by the abnormally low levels of certain blood cells called platelets, creating a condition known as thrombocytopenia. Platelets are specialized blood cells that help prevent and stop bleeding by inducing clotting. In ITP, there is no readily apparent cause or underlying disease (idiopathic). The cells of the immune system, lymphocytes, produce anti-platelet antibodies that attach to the platelets. The presence of antibodies on platelets leads to their destruction in the spleen. The disorder is characterized by abnormal bleeding into the skin resulting in bruising, which is what the term purpura means. Bleeding from mucous membranes also occurs, and may subsequently result in low levels of circulating red blood cells (anemia).

    ITP presents as a brief, self-limiting form of the disorder (acute ITP) or a longer-term form (chronic ITP). Acute ITP accounts for about 90% of cases, and chronic ITP accounts for the remainder. Eighty percent (80%) of the children with ITP have the acute form while the chronic form affects mostly adults. The acute form usually resolves without treatment (spontaneously) within three to six months. When thrombocytopenia lasts for more than six to 12 months, ITP is classified as the chronic form. Onset of acute ITP is often rapid, while the onset of the chronic form may be gradual.

    Organizations related to Idiopathic Thrombocytopenic Purpura
    • American Autoimmune Related Diseases Association, Inc.
      22100 Gratiot Avenue
      Eastpointe MI 48021
      Phone #: 586-776-3900
      800 #: 800-598-4668
      e-mail: [email protected]
      Home page: http://www.aarda.org/
    • AutoImmunity Community
      None None None
      Phone #: (91-9) -552-9057
      800 #: N/A
      e-mail: [email protected]
      Home page: http://autoimmunitycommunity.org
    • Autoimmune Information Network, Inc
      PO Box 4121
      Brick NJ 08723
      Phone #: 732-664-9259
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.aininc.org
    • European Society for Immunodeficiencies (ESID)
      c/o Dr. Esther de Vries
      Hertogenbosch None 5200 ME's
      Phone #: +31- 73--6992965
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.esid.org
    • ITP Foundation
      381 Post Rd
      Darien CT 06820
      Phone #: 203-655-6954
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.itpfoundation.org
    • ITP People Place
      P.O. Box 61533
      Potomac MD 20859
      Phone #: 301-770-6636
      800 #: 877-528-3538
      e-mail: [email protected]
      Home page: http://www.itppeople.com
    • ITP Society of the Children's Blood Foundation
      Children's Blood Foundation
      New York NY 10016
      Phone #: 212-297-4336
      800 #: 800-487-7010
      e-mail: N/A
      Home page: http://www.childrensbloodfoundation.org/
    • ITP Support Association
      Synehurst, Kimbolton Road
      Bolnhurst, Beds None MK44 2EW
      Phone #: 011-44 -0870 777 0559
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.itpsupport.org.uk
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: [email protected]
      Home page: http://www.netnet.net/mums/
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.madisonsfoundation.org
    • NIH/Hematology Branch, National Heart, Lung and Blood Institute (NHLBI)
      10 Center Dr, Building 10-CRC
      Bethesda MD 20892-1202
      Phone #: 301-402-0764
      800 #: --
      e-mail: [email protected]
      Home page: http://dir.nhlbi.nih.gov/labs/hb/index.asp?
    • NIH/National Heart, Lung and Blood Institute Information Center
      P.O. Box 30105
      Bethesda MD 20824-0105
      Phone #: 301-592-8573
      800 #: --
      e-mail: [email protected]
      Home page: N/A
    • Platelet Disorder Support Association
      133 Rollins Avenue
      Rockville MD 20852
      Phone #: 301-770-6636
      800 #: 877-528-3538
      e-mail: [email protected]
      Home page: http://www.pdsa.org

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html