Diseases & Conditions



Synonyms of Sarcoidosis
  • Sarcoid of Boeck
  • Schaumann's Disease

Disorder Subdivisions

  • Acute Sarcoidosis; Heerferdt-Waldenstrom and Lofgren's Syndromes (Included)
  • Chronic Sarcoidosis
  • Subacute Sarcoidosis

General Discussion
Sarcoidosis is a multisystem disorder that most often affects individuals between 20 and 40 years of age. Females appear to be affected more frequently than males. Sarcoidosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) consisting of certain granular white blood cells (modified macrophages or epithelioid cells) in certain organs of the body. The granulomas that are formed are thought to alter the normal structure of and, potentially, the normal functions of, the affected organ(s), causing symptoms associated with the particular body system(s) in question. In individuals with sarcoidosis, such granuloma formation most commonly affects the lungs. However, in many cases, the upper respiratory system, lymph nodes, skin, and/or eyes may be involved. In addition, in some cases, other organs may be affected, including the liver, bone marrow, spleen, musculoskeletal system, heart, salivary glands, and/or nervous system (i.e., central or peripheral nervous system).

The range and severity of symptoms associated with sarcoidosis vary greatly, depending upon the specific organ(s) involved and the degree of such involvement. In some cases, the symptoms of sarcoidosis may begin suddenly (acute), sometimes severely, and subside in a relatively short period of time (self limited). Acute sarcoidosis is often characterized by fatigue, fever, generalized muscle aches, difficulty breathing (dyspnea), joint pain, swollen glands, skin eruptions, eye irregularities, and/or other symptoms. In the subacute form, affected individuals may experience no symptoms (asymptomatic), even with organ involvement. In the chronic form of sarcoidosis, symptoms may appear slowly and subtly, and may persist or recur over a long time span. Initial symptoms of the chronic form of the disorder may include difficulty breathing (dyspnea), dry cough, limited airflow, and other respiratory abnormalities. Symptoms associated with other organ involvement may follow.

The exact cause of sarcoidosis is not known. However, possible infectious, environmental, genetic, and immunological factors are under investigation as potential causes of the disorder.

Organizations related to Sarcoidosis
  • American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Avenue
    Eastpointe MI 48021
    Phone #: 586-776-3900
    800 #: 800-598-4668
    e-mail: [email protected]
    Home page: http://www.aarda.org/
  • American Lung Association
    61 Broadway, 6th Floor
    New York NY 10006
    Phone #: 212-315-8700
    800 #: 800-586-4872
    e-mail: N/A
    Home page: http://www.lungusa.org
  • AutoImmunity Community
    None None None
    Phone #: (91-9) -552-9057
    800 #: N/A
    e-mail: [email protected]
    Home page: http://autoimmunitycommunity.org
  • Autoimmune Information Network, Inc
    PO Box 4121
    Brick NJ 08723
    Phone #: 732-664-9259
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.aininc.org
  • Erythema Nodosum Yahoo Support Group
    None None None
    Phone #: N/A
    800 #: N/A
    e-mail: N/A
    Home page: http://health.groups.yahoo.com/group/erythema_nodosum_Group/
  • European Society for Immunodeficiencies (ESID)
    c/o Dr. Esther de Vries
    Hertogenbosch None 5200 ME's
    Phone #: +31- 73--6992965
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.esid.org
  • Foundation for Sarcoidosis Research
    122 South Michigan Avenue, Suite 1700
    Chicago IL 60603
    Phone #: 312-341-0500
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.stopsarcoidosis.org
  • Jack Miller Center for Peripheral Neuropathy
    University of Chicago
    Chicago IL 60637
    Phone #: 773-702-5800
    800 #: N/A
    e-mail: [email protected]
    Home page: http://millercenter.uchicago.edu
  • Janine Sarcoidosis Outreach Foundation
    12600 Bissonnet
    Houston TX 77099
    Phone #: 832-248-6621
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.jsof.org
  • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: [email protected]
    Home page: http://www.netnet.net/mums/
  • Madisons Foundation
    PO Box 241956
    Los Angeles CA 90024
    Phone #: 310-264-0826
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.madisonsfoundation.org
  • NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
    1 AMS Circle
    Bethesda MD 20892-3675
    Phone #: 301-495-4484
    800 #: 877-226-4267
    e-mail: [email protected]
    Home page: http://www.niams.nih.gov/Health_Info
  • NIH/National Eye Institute
    Building 31 Rm 6A32
    Bethesda MD 20892-2510
    Phone #: 301-496-5248
    800 #: --
    e-mail: [email protected]
    Home page: http://www.nei.nih.gov/
  • NIH/National Heart, Lung and Blood Institute Information Center
    P.O. Box 30105
    Bethesda MD 20824-0105
    Phone #: 301-592-8573
    800 #: --
    e-mail: [email protected]
    Home page: N/A
  • National Sarcoidosis Resource Center
    P.O. Box 1593
    Piscataway NJ 08855-1593
    Phone #: 732-469-4087
    800 #: --
    e-mail: [email protected]
    Home page: http://www.nsrc-global.net
  • Sarcoidosis Center
    6005 Park Ave
    Memphis TN 38119
    Phone #: 901-761-5877
    800 #: N/A
    e-mail: [email protected]
    Home page: http://www.sarcoidcenter.com
  • Sarcoidosis Networking Association
    6201 Pacific Avenue
    Tacoma WA 98408
    Phone #: 253-826-7737
    800 #: --
    e-mail: [email protected]
    Home page: http://www.sarcoidosisnetwork.org
  • Sarcoidosis Online Sites: A Comprehensive Source for Sarcoidosis Information on the Internet
    None None None
    Phone #: --
    800 #: --
    e-mail: [email protected]
    Home page: http://www.sarcoidosisonlinesites.com
  • Sarcoidosis Research Institute
    3475 Central Avenue
    Memphis TN 38111
    Phone #: 901-219-6883
    800 #: --
    e-mail: [email protected]
    Home page: http://www.sarcoidosisresearch.org/
  • Uveitis/OID Support Group
    5 Cambridge Center
    Cambridge MA 02142
    Phone #: 617-621-6377
    800 #: 866-353-6377
    e-mail: [email protected]
    Home page: http://www.uveitis.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html