Diseases & Conditions


Triplo X Syndrome

Synonyms of Triplo X Syndrome
  • 47,XXX Chromosome Constitution
  • 47,XXX Karyotype
  • 47,XXX Syndrome
  • Triple X Syndrome
  • Trisomy X

Disorder Subdivisions

    General Discussion
    Triplo X Syndrome is a chromosomal abnormality that affects females. Females normally have two X chromosomes; however, those with Triplo X Syndrome carry three X chromosomes (trisomy X) in the nuclei of body cells. No specific pattern of symptoms and malformations (phenotype) has been found to be associated with this abnormal chromosomal make-up (i.e., 47,XXX karyotype). Many affected females appear to have no or very few associated symptoms, while others may have various abnormalities.

    However, investigators indicate that Triplo X Syndrome is a relatively common cause of learning difficulties, particularly language-based disabilities (e.g., dyslexia), in females. Evidence suggests that affected females typically have normal intelligence with IQs that tend to be lower than that of their brothers and sisters (siblings). Mental retardation rarely occurs. Infants and children with Triplo X Syndrome may tend to have delayed acquisition of certain motor skills and delayed language and speech development.

    Affected females often are of tall stature. According to researchers, although sexual development and fertility are usually normal, some may have delayed puberty and/or fertility problems. In addition, in some cases, certain physical abnormalities have been reported, such as a relatively small head, vertical skin folds that may cover the eyes' inner corners (epicanthal folds), and/or other findings. Triplo X Syndrome results from errors during the division of reproductive cells in one of the parents.

    Organizations related to Triplo X Syndrome
    • International Dyslexia Association
      Chester Building
      Baltimore MD 21286-2044
      Phone #: 410-296-0232
      800 #: 800-222-3123
      e-mail: [email protected]
      Home page: http://www.interdys.org
    • Klinefelter Syndrome & Associates (KS&A)
      11 Keats Court
      Coto de Caza CA 92679
      Phone #: 888-999-9428
      800 #: 888-999-9428
      e-mail: [email protected]
      Home page: http://www.genetic.org
    • Learning Disabilities Association of America
      4156 Library Road
      Pittsburgh PA 15234-1349
      Phone #: 412-341-1515
      800 #: 888-300-6710
      e-mail: [email protected]
      Home page: http://www.ldaamerica.org
    • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
      150 Custer Court
      Green Bay WI 54301-1243
      Phone #: 920-336-5333
      800 #: 877-336-5333
      e-mail: [email protected]
      Home page: http://www.netnet.net/mums/
    • Madisons Foundation
      PO Box 241956
      Los Angeles CA 90024
      Phone #: 310-264-0826
      800 #: N/A
      e-mail: [email protected]
      Home page: http://www.madisonsfoundation.org
    • March of Dimes Birth Defects Foundation
      1275 Mamaroneck Avenue
      White Plains NY 10605
      Phone #: 914-428-7100
      800 #: 888-663-4637
      e-mail: [email protected]
      Home page: http://www.marchofdimes.com
    • National Center for Learning Disabilities
      381 Park Avenue South
      New York NY 10016
      Phone #: 212-545-7510
      800 #: 888-575-7373
      e-mail: [email protected]
      Home page: http://www.ld.org
    • National Dissemination Center for Children with Disabilities
      P.O. Box 1492
      Washington D.C. 20013
      Phone #: 202-884-8200
      800 #: 800-695-0285
      e-mail: [email protected]
      Home page: http://www.nichcy.org
    • UNIQUE - Rare Chromosome Disorder Support Group
      P.O. Box 2189
      Surrey Intl CR3 5GN
      Phone #: 44 -0 1-883 330766
      800 #: --
      e-mail: [email protected]
      Home page: http://www.rarechromo.org

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html