Triplo X Syndrome / Disease

Diseases & Conditions

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Triplo X Syndrome

Synonyms of Triplo X Syndrome

47,XXX Chromosome Constitution
47,XXX Karyotype
47,XXX Syndrome
Triple X Syndrome
Trisomy X

Disorder Subdivisions

General Discussion
Triplo X Syndrome is a chromosomal abnormality that affects females. Females normally have two X chromosomes; however, those with Triplo X Syndrome carry three X chromosomes (trisomy X) in the nuclei of body cells. No specific pattern of symptoms and malformations (phenotype) has been found to be associated with this abnormal chromosomal make-up (i.e., 47,XXX karyotype). Many affected females appear to have no or very few associated symptoms, while others may have various abnormalities.

However, investigators indicate that Triplo X Syndrome is a relatively common cause of learning difficulties, particularly language-based disabilities (e.g., dyslexia), in females. Evidence suggests that affected females typically have normal intelligence with IQs that tend to be lower than that of their brothers and sisters (siblings). Mental retardation rarely occurs. Infants and children with Triplo X Syndrome may tend to have delayed acquisition of certain motor skills and delayed language and speech development.

Affected females often are of tall stature. According to researchers, although sexual development and fertility are usually normal, some may have delayed puberty and/or fertility problems. In addition, in some cases, certain physical abnormalities have been reported, such as a relatively small head, vertical skin folds that may cover the eyes' inner corners (epicanthal folds), and/or other findings. Triplo X Syndrome results from errors during the division of reproductive cells in one of the parents.
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Organizations related to Triplo X Syndrome

International Dyslexia Association
Chester Building
Baltimore MD 21286-2044
Phone #: 410-296-0232
800 #: 800-222-3123
e-mail: [email protected]
Home page: http://www.interdys.org
Klinefelter Syndrome & Associates (KS&A)
11 Keats Court
Coto de Caza CA 92679
Phone #: 888-999-9428
800 #: 888-999-9428
e-mail: [email protected]
Home page: http://www.genetic.org
Learning Disabilities Association of America
4156 Library Road
Pittsburgh PA 15234-1349
Phone #: 412-341-1515
800 #: 888-300-6710
e-mail: [email protected]
Home page: http://www.ldaamerica.org
MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay WI 54301-1243
Phone #: 920-336-5333
800 #: 877-336-5333
e-mail: [email protected]
Home page: http://www.netnet.net/mums/
Madisons Foundation
PO Box 241956
Los Angeles CA 90024
Phone #: 310-264-0826
800 #: N/A
e-mail: [email protected]
Home page: http://www.madisonsfoundation.org
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains NY 10605
Phone #: 914-428-7100
800 #: 888-663-4637
e-mail: [email protected]
Home page: http://www.marchofdimes.com
National Center for Learning Disabilities
381 Park Avenue South
New York NY 10016
Phone #: 212-545-7510
800 #: 888-575-7373
e-mail: [email protected]
Home page: http://www.ld.org
National Dissemination Center for Children with Disabilities
P.O. Box 1492
Washington D.C. 20013
Phone #: 202-884-8200
800 #: 800-695-0285
e-mail: [email protected]
Home page: http://www.nichcy.org
UNIQUE - Rare Chromosome Disorder Support Group
P.O. Box 2189
Surrey Intl CR3 5GN
Phone #: 44 -0 1-883 330766
800 #: --
e-mail: [email protected]
Home page: http://www.rarechromo.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ? (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html